Document Detail


Comparison of lipase activity in peritoneal fluid of dogs with different pathologies--a complementary diagnostic tool in acute pancreatitis?
MedLine Citation:
PMID:  16533326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A clinical diagnosis of acute pancreatitis is often difficult to obtain. Histopathology remains the gold standard, whereas clinical signs, diagnostic imaging and laboratory testing, even in combination, may be insufficient. In a prospective study, lipase activity in ascitic fluid of various aetiologies was determined in 44 dogs in order to investigate its performance in cases of acute pancreatitis. Data of simultaneously determined blood lipase activities were available in 27 dogs. Lipase activity was measured by a colorimetric assay. A complete peritoneal fluid analysis was performed. Dogs were divided into four groups, according to their final diagnosis: acute pancreatitis (A), abdominal trauma (B), abdominal neoplasia (C) and others (hepatic or cardiac diseases) (D). Dogs with acute pancreatitis had a significantly higher peritoneal lipase activity than those in other groups (P < or = 0.024), while no significant difference was found between the other groups (P > or = 0.734). Blood lipase activity as well as protein content and total cell count of the ascitic fluid did not show any significant difference between groups. Data show that determination of lipase activity in dogs that develop ascites may be useful in complementing the diagnosis of acute pancreatitis.
Authors:
A Guija de Arespacochaga; K M Hittmair; I Schwendenwein
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine     Volume:  53     ISSN:  0931-184X     ISO Abbreviation:  J Vet Med A Physiol Pathol Clin Med     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-14     Completed Date:  2006-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100955112     Medline TA:  J Vet Med A Physiol Pathol Clin Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  119-22     Citation Subset:  IM    
Affiliation:
Central Laboratory, University of Veterinary Medicine, Vienna, Austria. abigail.guija@vu-wien.ac.at
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MeSH Terms
Descriptor/Qualifier:
Abdominal Injuries / diagnosis,  enzymology,  veterinary
Abdominal Neoplasms / diagnosis,  enzymology,  veterinary
Acute Disease
Animals
Ascites / enzymology
Ascitic Fluid / enzymology*
Biological Markers / blood,  metabolism
Colorimetry / methods,  veterinary
Diagnosis, Differential
Dog Diseases / diagnosis*,  enzymology
Dogs
Female
Heart Diseases / diagnosis,  enzymology,  veterinary
Lipase / metabolism*
Liver Diseases / diagnosis,  enzymology,  veterinary
Male
Pancreatitis / diagnosis,  enzymology,  veterinary*
Chemical
Reg. No./Substance:
0/Biological Markers; EC 3.1.1.3/Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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