Document Detail

Comparison of linkage maps of mouse chromosome 12 derived from laboratory strain intraspecific and Mus spretus interspecific backcrosses.
MedLine Citation:
PMID:  2570028     Owner:  NLM     Status:  MEDLINE    
Progeny from an interspecific backcross between laboratory mice and Mus spretus were typed for inheritance of eight genetic markers on chromosome 12. Marker order determined by segregation analyses of 115 meiotic events was in good agreement with that determined previously using intraspecific laboratory strain backcrosses. Two additional markers, D12Nyu5 and Lamb-1, previously not ordered, were located in the middle of the interval between D12Nyu12 and D12Nyu1. Marker spacing was reduced in the interspecific cross relative to that observed in intraspecific crosses. Furthermore, the interspecific cross was characterized by marked deviation from 1:1 segregation in the recombinant chromosomes and very strong positive interference. These data suggest that comparisons of different mouse crosses may facilitate the understanding of underlying mechanisms that govern recombination events in complex genomes.
M F Seldin; T A Howard; P D'Eustachio
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  5     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-29     Completed Date:  1989-09-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
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MeSH Terms
Chromosome Mapping*
Crosses, Genetic
DNA / genetics
Data Interpretation, Statistical
Genetic Markers
Linkage (Genetics)*
Mice, Inbred C3H
Mice, Inbred C57BL
Muridae / genetics*
Polymorphism, Restriction Fragment Length
Recombination, Genetic
Grant Support
Reg. No./Substance:
0/Genetic Markers; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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