| Comparison of levofloxacin-containing sequential and standard triple therapies for the eradication of Helicobacter pylori. | |
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MedLine Citation:
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PMID: 22284248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is an important concern about the success of standard triple treatment for Helicobacter pylori (H. pylori) in recent years. Better eradication rates have been reported with sequential treatment in current studies. This study aimed to compare the success of a novel levofloxacin-containing sequential regimen with standard triple therapy. METHODS: H. pylori-positive patients with non-ulcer dyspepsia were randomly allocated to one of the study groups. The patients on sequential arm were given esomeprazole 40 mg BID and amoxicillin 1g BID for the first week followed by esomeprazole 40 mg BID, levofloxacin 500 mg QD and metronidazole 500 mg TID for the second week. The patients on standard triple arm were given esomeprazole 40 mg BID, amoxicillin 1g BID and clarithromycin 500 mg BID for 2 weeks. Eradication was assessed by urea breath test on 6th weeks. RESULTS: Seventy-five patients were enrolled in each group; 72 in sequential arm and 67 in standard arm completed the protocols. H. pylori eradication rate of per protocol was 90% in sequential versus 57% in standard treatment groups with a statistical significance (p<0.000). Both regimens were similarly well tolerated and side effects were comparable. Only one patient in sequential arm stopped the treatment because of side effects. CONCLUSION: The levofloxacin-containing sequential therapy is a significantly better strategy than the standard triple treatment for H. pylori eradication. Standard triple treatment is no more effective for H. pylori in our population and levofloxacin-containing sequential regimen might be used as a first-line eradication option. |
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Authors:
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Zulfikar Polat; Abdurrahman Kadayifci; Murat Kantarcioglu; Ayhan Ozcan; Ozdes Emer; Ahmet Uygun |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2011-03-17 |
Journal Detail:
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Title: European journal of internal medicine Volume: 23 ISSN: 1879-0828 ISO Abbreviation: Eur. J. Intern. Med. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-01-30 Completed Date: 2012-06-26 Revised Date: 2013-01-07 |
Medline Journal Info:
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Nlm Unique ID: 9003220 Medline TA: Eur J Intern Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 165-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Gastroenterology, Gulhane Military Medical Academy, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Amoxicillin / administration & dosage, therapeutic use Anti-Bacterial Agents / administration & dosage*, therapeutic use Dose-Response Relationship, Drug Drug Therapy, Combination Enzyme Inhibitors / administration & dosage*, therapeutic use Esomeprazole Sodium / administration & dosage, therapeutic use Female Follow-Up Studies Helicobacter Infections / drug therapy*, microbiology Helicobacter pylori / isolation & purification* Humans Male Middle Aged Ofloxacin / administration & dosage*, therapeutic use Retrospective Studies Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Enzyme Inhibitors; 26787-78-0/Amoxicillin; 82419-36-1/Ofloxacin; L2C9GWQ43H/Esomeprazole Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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