Document Detail

Comparison of levels of serum matrix metalloproteinase-9 in patients with acute myocardial infarction versus unstable angina pectoris versus stable angina pectoris.
MedLine Citation:
PMID:  16442358     Owner:  NLM     Status:  MEDLINE    
Matrix metalloproteinases (MMPs) are important for resorption of extracellular matrixes and may degrade the fibrous cap of an atherosclerotic plaque, thus contributing to coronary plaque rupture. Histologic studies have shown MMP expression in lesions of acute coronary syndrome. In this study, we evaluated the relation between plaque morphology as obtained by intravascular ultrasound before percutaneous coronary intervention and serum MMP levels in patients who had coronary artery disease. We enrolled consecutive 47 patients who had acute myocardial infarction (AMI), 23 who had unstable angina pectoris (UAP), and 19 who had stable effort angina pectoris and underwent intravascular ultrasound before percutaneous coronary intervention followed by successful primary percutaneous coronary intervention. Peripheral blood was obtained from all patients before angiography and serum levels of MMP-1,-2, and -9 were analyzed. Serum levels of MMP-9 in the AMI and UAP groups were significantly higher than that in the stable effort angina pectoris group (p = 0.007 and 0.04, respectively). From the intravascular ultrasound findings before percutaneous coronary intervention, plaque rupture was detected in 26 patients (55%) in the AMI group and in 11 patients (48%) in the UAP group. In these 2 groups, patients with plaque rupture had significantly higher levels of MMP-9 than patients who did not have plaque rupture (p = 0.03 and 0.01, respectively). Multiple logistic regression analysis showed that MMP-9 was the only independent predictor of plaque rupture (p = 0.004). In conclusion, high levels of MMP-9 in patients who have AMI and UAP are related to the presence of plaque rupture in the culprit lesion.
Daiju Fukuda; Kenei Shimada; Atsushi Tanaka; Takanori Kusuyama; Hajime Yamashita; Shoichi Ehara; Yasuhiro Nakamura; Takahiko Kawarabayashi; Hidetaka Iida; Minoru Yoshiyama; Junichi Yoshikawa
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-11-17
Journal Detail:
Title:  The American journal of cardiology     Volume:  97     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-30     Completed Date:  2006-03-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175-80     Citation Subset:  AIM; IM    
Department of Internal Medicine, Cardiology Graduate School of Medicine, Osaka City University Medical School, Osaka, Japan.
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MeSH Terms
Angina Pectoris / blood*
Coronary Artery Disease / blood,  ultrasonography
Logistic Models
Matrix Metalloproteinase 9 / blood*
Middle Aged
Myocardial Infarction / blood*
Ultrasonography, Interventional
Reg. No./Substance:
EC Metalloproteinase 9

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