| Comparison of leucine kinetics in endurance-trained and sedentary humans. | |
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MedLine Citation:
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PMID: 9887146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whole body leucine kinetics was compared in endurance-trained athletes and sedentary controls matched for age, gender, and body weight. Kinetic studies were performed during 3 h of rest, 1 h of exercise (50% maximal oxygen consumption), and 2 h of recovery. When leucine kinetics were expressed both per unit of body weight and per unit of fat-free mass, both groups demonstrated an increase in leucine oxidation during exercise (P < 0.01). Trained athletes had a greater leucine rate of appearance during exercise and recovery compared with their sedentary counterparts (P < 0.05) and an increased leucine oxidation at all times on the basis of body weight (P < 0.05). However, all of these between-group differences were eliminated when leucine kinetics were corrected for fat-free tissue mass. Therefore, correction of leucine kinetics for fat-free mass may be important when cross-sectional investigations on humans are performed. Furthermore, leucine oxidation, when expressed relative to whole-body oxygen consumption during exercise, was similar between groups. It is concluded that there was no difference between endurance-trained and sedentary humans in whole body leucine kinetics during rest, exercise, or recovery when expressed per unit of fat-free tissue mass. |
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Authors:
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L S Lamont; A J McCullough; S C Kalhan |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 86 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-03-15 Completed Date: 1999-03-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 320-5 Citation Subset: IM; S |
Affiliation:
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Exercise Science Program, University of Rhode Island, Kingston, Rhode Island 02881, USA.LAMONT@URIACC.URI.EDU |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / metabolism Body Composition Body Weight / physiology Female Humans Keto Acids / blood Leucine / pharmacokinetics* Male Oxygen Consumption / physiology Physical Endurance / physiology* Physical Fitness / physiology* Pulmonary Gas Exchange |
| Grant Support | |
ID/Acronym/Agency:
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HD-11089/HD/NICHD NIH HHS; RR-00080/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Keto Acids; 61-90-5/Leucine; 816-66-0/alpha-ketoisocaproic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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