Document Detail

Comparison of lens thickness measurements using the anterior segment optical coherence tomography and A-scan ultrasonography.
MedLine Citation:
PMID:  18775858     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess lens thickness (LT) measurements with anterior segment optical coherence tomography (AS-OCT) in comparison with A-scan ultrasonography (A-scan US). METHODS: Enrolled were 66 eyes of 48 phakic elderly volunteers aged > or = 50 years and 56 eyes of 56 young participants aged 18 to 40 years. LT was measured with the internal manual caliper tools in AS-OCT. The A-scan US measurements were based on an average of 10 consecutive automatic measurements. Reproducibility was assessed by three measurements each with AS-OCT and A-scan US independently obtained by two observers who were masked to one another's results. RESULTS: The failure rates of AS-OCT and A-scan US were 9.1% and 7.6%, respectively, in elderly subjects, but no failure was observed in young subjects. The LT values measured by AS-OCT were significantly greater than A-scan US; the paired difference was 0.135 mm in elderly and 0.101 mm in young subjects (P < 0.001). These differences did not correlate with the nuclear cataract grades (r = 0.078, P = 0.558). Intraobserver agreement on AS-OCT (95% limits of agreement [LoA]: -0.049 to +0.045 mm; ICC: 0.999) was better than A-scan US (95%LoA: -0.194 to +0.218 mm; ICC: 0.974). The 95% LoA of interobserver agreement using AS-OCT and A-scan were -0.084 to +0.073 and -0.278 to +0.239 mm, respectively, and the ICCs were 0.996 and 0.960, respectively. CONCLUSIONS: AS-OCT can be used to measure lens thickness in most eyes with clear or opacified lenses. It appears to be an alternative means of measuring lens thickness, particularly when a noncontact method is needed.
Yangfa Zeng; Yizhi Liu; Xing Liu; Chuying Chen; Yuanling Xia; Miaoling Lu; Mingguang He
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-09-04
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  50     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-06     Completed Date:  2009-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  290-4     Citation Subset:  IM    
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China.
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MeSH Terms
Aged, 80 and over
Cataract / diagnosis*,  ultrasonography
Diagnostic Techniques, Ophthalmological*
Lens, Crystalline / pathology*,  ultrasonography
Middle Aged
Observer Variation
Reproducibility of Results
Tomography, Optical Coherence / methods
Ultrasonography / methods
Young Adult

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