Document Detail


Comparison of late enhancement cardiovascular magnetic resonance and thallium SPECT in patients with coronary disease and left ventricular dysfunction.
MedLine Citation:
PMID:  15137339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Late enhancement magnetic resonance imaging (MRI) was compared with thallium-201 rest-redistribution single photon emission computed tomography (SPECT) in patients with reduced left ventricular (LV) function and prior myocardial infarction (MI). BACKGROUND: Hyperenhancement on contrast cardiac MRI using gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) has been reported to identify nonviable myocardium. Comparisons of MRI and thallium-201 SPECT have recently been reported. This study focuses on the comparison of these modalities specifically in patients with ischemic heart failure, where viability determination is most clinically relevant. METHODS: Fifteen patients with LV dysfunction and prior MI [mean ejection fraction (EF) 35 +/- 11%] underwent thallium-201 rest-redistribution scintigraphy and contrast MRI on separate days. Each short axis slice was divided into six 60-degree segments, and correlations between MRI and scintigraphy were made on viability detection for each segment. For SPECT, the mean uptake score was calculated from the average of all percent relative activity values throughout each segment. Areas with < 50% of maximal thallium uptake were considered nonviable. On MRI, regions with increased signal intensity after an injection of 0.1 mmol/kg Gd-DPTA were considered nonviable. RESULTS: A total of 558 segments were analyzed. Overall, there was a strong inverse relationship between the area of hyperenhancement on MRI and diminished thallium-201 uptake on SPECT (r = -0.51, P < 0.001). There was a significant correlation between the imaging methods for each individual segment, except for the inferior-septal segment (r = -0.38, P < 0.08). CONCLUSIONS: In patients with LV dysfunction and prior MI, our data suggest MRI hyperenhancement significantly correlates with myocardial nonviability by thallium-201 SPECT. Correlations were weaker in the inferior-septal region, which may be due to SPECT attenuation artifact.
Authors:
Maria Ansari; Phillip A Araoz; Stephen K Gerard; Norbert Watzinger; Gunnar K Lund; Barry M Massie; Charles B Higgins; David A Saloner
Related Documents :
15855069 - Neuropsychiatric systemic lupus erythematosus: correlation of brain mr imaging, ct, and...
17021429 - Usefulness of 99mtc-technegas and 133xe dynamic spect in ventilatory impairment.
8853909 - Superimposition of in-111 platelet spect and ct/mr imaging in intracardiac thrombus.
16686019 - A new method for spect quantification of targeted radiotracers uptake in the myocardium.
11792039 - The correlation between 99mtc-mibi uptake and mib-1 as a nuclear proliferation marker i...
9258969 - Electrophysiological brainstem dysfunction in a child with leigh disease.
20634769 - [18f] fdg pet/ct in patients with fever of unknown origin: a local experience.
20011419 - Magnetic resonance imaging in the management of anal fistula and anorectal sepsis.
20043339 - A novel noninvasive ultrasonic cardiac output monitor: comparison with cardiac magnetic...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance     Volume:  6     ISSN:  1097-6647     ISO Abbreviation:  J Cardiovasc Magn Reson     Publication Date:  2004  
Date Detail:
Created Date:  2004-05-12     Completed Date:  2004-09-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9815616     Medline TA:  J Cardiovasc Magn Reson     Country:  United States    
Other Details:
Languages:  eng     Pagination:  549-56     Citation Subset:  IM    
Affiliation:
Division of Cardiology, University of California, San Francisco, Radiology Service, San Francisco VA Medical Center, San Francisco, California, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Contrast Media
Coronary Artery Disease / pathology,  radionuclide imaging
Gadolinium DTPA / diagnostic use
Humans
Image Enhancement / methods
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Myocardial Infarction / pathology,  radionuclide imaging
Myocardium / pathology*
Prospective Studies
Thallium Radioisotopes / diagnostic use*
Tomography, Emission-Computed, Single-Photon / methods*
Ventricular Dysfunction, Left / pathology,  radionuclide imaging
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Thallium Radioisotopes; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Influence of contrast agent dose and image acquisition timing on the quantitative determination of n...
Next Document:  MRI of arrhythmogenic right ventricular cardiomyopathy/dysplasia.