Document Detail

Comparison of latanoprost monotherapy to dorzolamide combined with timolol in patients with glaucoma and ocular hypertension.A 3-month randomised study.
MedLine Citation:
PMID:  10664047     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of the study was to compare the effects on intraocular pressure (IOP) of adding dorzolamide to timolol or of switching from timolol to latanoprost monotherapy in glaucoma patients inadequately controlled on timolol. METHODS: The study was designed as a 3-month randomised, open-label, multicentre study comprising 183 patients with primary open-angle glaucoma, capsular glaucoma with IOP above 22 mmHg on treatment with one or two ocular hypotensive drugs, or ocular hypertension with IOP above 27 mmHg. After a 2- to 4-week run-in period on timolol, 0.5% twice daily, the patients were randomised to treatment with either latanoprost, 0. 005% once daily, or the combination of timolol, 0.5% twice daily, and dorzolamide, 2% twice daily. The mean diurnal IOP after 3 months of treatment was compared with baseline. RESULTS: Switching from timolol to latanoprost reduced mean diurnal IOP by 4.5+/-0.2 mmHg (mean+/-SEM, ANCOVA; 20%), and adding dorzolamide to timolol reduced mean diurnal by 4.4+/-0.2 mmHg (mean+/-SEM, ANCOVA; 20%). No serious side effects were observed with either treatment. CONCLUSION: Latanoprost monotherapy can be an alternative to combined treatment with two aqueous flow suppressors in patients whose IOP is insufficiently controlled by timolol alone.
K H Emmerich
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  238     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-03     Completed Date:  2000-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  19-23     Citation Subset:  IM    
Eye Clinic, Darmstadt Municipal Hospitals, D-64297 Darmstadt, Germany.
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MeSH Terms
Adrenergic beta-Antagonists / administration & dosage,  therapeutic use*
Aged, 80 and over
Antihypertensive Agents / administration & dosage,  therapeutic use*
Circadian Rhythm
Drug Therapy, Combination
Follow-Up Studies
Glaucoma, Open-Angle / drug therapy*,  physiopathology
Intraocular Pressure / drug effects
Middle Aged
Ocular Hypertension / drug therapy*,  physiopathology
Ophthalmic Solutions
Prostaglandins F, Synthetic / administration & dosage,  therapeutic use*
Sulfonamides / administration & dosage,  therapeutic use*
Thiophenes / administration & dosage,  therapeutic use*
Timolol / administration & dosage,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 0/Ophthalmic Solutions; 0/Prostaglandins F, Synthetic; 0/Sulfonamides; 0/Thiophenes; 130209-82-4/latanoprost; 130693-82-2/dorzolamide; 26839-75-8/Timolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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