Document Detail

Comparison of lactate and bicarbonate buffered haemofiltration fluids: use in critically ill patients.
MedLine Citation:
PMID:  9198053     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare acid-base balance, lactate concentration, and haemodynamic and O2 transport variables during haemofiltration with replacement fluid containing 44.5 mmol/l Na+ lactate or 40 mmol/l Na+ HCO3- and 3 mmol/l lactic acid. DESIGN: A prospective, randomized trial. SETTING: A multidisciplinary, adult intensive care unit in a university hospital. PATIENTS: Forty acidotic patients who required haemofiltration, were dependent on mechanical ventilation, and had PA catheters in situ. INTERVENTIONS: During haemofiltration patients received lactate or bicarbonate replacement fluid at a mean rate of 1.7 l/h (SD 0.3). Arterial blood gases, plasma lactate, and haemodynamic and O2 transport variables were measured before and after 12 and 24 h haemofiltration. Ultrafiltrate was collected for lactate estimation. MEASUREMENTS AND MAIN RESULTS: As means (SD). The net gain of lactate was 63 mmol/h (12 mmol) with Na+ lactate and 0 mmol/h (0.3 mmol) with Na+ HCO3-. There was a significant increase in pH and [lactate] in both groups, but [lactate] was higher in patients receiving lactate. Twenty-one patients survived to ICU discharge, these patients were significantly less acidotic after filtration (lactate group: 0 h: pH 7.23 (0.09), [lactate] 2.4 mmol/l (1.7); 12 h: pH 7.34 (0.09), [lactate] 4.7 mmol/l (2.4); 24 h: pH 7.36 (0.07), [lactate] 4.7 mmol (2.7). HCO3 group: 0 h: pH 7.23 (0.09), [lactate] 2.3 (1.3); 12 h: pH 7.32 (0.06), [lactate] 2.9 mmol/l (1.8); 24 h: pH 7.35 (0.08), [lactate] 2.8 mmol/l (2.0). Base deficit: survivors: 0 h: 9 mmol/l (4); 12 h: 2 mmol/l (3). Non-survivors: 0 h: 10 mmol/l (3); 12 h: 6 mmol/l (3)). Haemodynamic and O2 transport variables were not significantly affected by treatment group or outcome. CONCLUSIONS: The degree of correction of acidosis during the first 24 h of haemofiltration was determined by patients outcome but was not affected by the substitution of bicarbonate- for lactate-containing replacement fluids.
A N Thomas; J M Guy; R Kishen; I F Geraghty; B J Bowles; P Vadgama
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  12     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-29     Completed Date:  1997-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1212-7     Citation Subset:  IM    
Department of Intensive Care, Hope Hospital, Salford, UK.
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MeSH Terms
Acidosis / therapy*
Bicarbonates / administration & dosage*
Critical Illness*
Lactic Acid / administration & dosage*
Prospective Studies
Reg. No./Substance:
0/Bicarbonates; 0/Buffers; 50-21-5/Lactic Acid

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