| Comparison of isosorbide mononitrate and misoprostol for cervical ripening in termination of pregnancy between 8 and 12 weeks: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 20549511 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: The present study was undertaken to compare the efficacy of isosorbide mononitrate (IMN) and misoprostol for cervical ripening in termination of pregnancy between 8 and 12 weeks. MATERIALS AND METHODS: This prospective randomized single blind study enrolled 40 women with singleton pregnancy seeking surgical termination of pregnancy between 8 and 12 weeks of gestation. They were divided into two groups-group I received IMN 40 mg while group II received misoprostol 40 mg vaginally, 3 h prior to suction and evacuation. All women were monitored for effects of cervical ripening and adverse effects. RESULTS: The mean sizes of dilators that could be negotiated without any resistance was 5.9 ± 1.33 in group I and 8.6 ± 0.94 in group II (p < 0.001, 95% CI 0.58, 0.41). The mean dilator sizes at which resistance was first encountered was 6.9 ± 1.37 in group I and 9.9 ± 1.23 in group II (p < 0.001, 95% CI 0.60, 0.54). The mean blood loss was 61.5 ± 13.86 ml in group I and 36.25 ± 12.80 ml in group II (p < 0.001, 95% CI 6.07, 5.63). Headache was the most common adverse effect seen with IMN use. CONCLUSION: The results show that IMN has a definite role and better safety profile than misoprostol in first trimester cervical ripening, although misoprostol is more effective and causes less blood loss. |
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Authors:
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Nirmala Duhan; Sonam Gupta; Krishna Dahiya; Daya Sirohiwal; Seema Rohilla |
Publication Detail:
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Type: Journal Article Date: 2010-06-13 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: 283 ISSN: 1432-0711 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
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Languages: eng Pagination: 1245-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, H. No. 6/9J, Medical Campus, Rohtak, 124001, Haryana, India, nkadian@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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