Document Detail

Comparison of ionic and non-ionic nitroxide spin labels for urographic enhancement in magnetic resonance imaging.
MedLine Citation:
PMID:  2960354     Owner:  NLM     Status:  MEDLINE    
Two nitroxide spin labels (NSL) were compared for in vitro relaxivity and in normal rats for efficiency of urographic enhancement. One of the NSL, PCA, a pyrrolidinyl agent, was ionic and one, NAT, was a non-ionic pyrrolidinyl NSL with multiple hydroxyl substituents for water solubility. Using both NSLs the renal medulla and papilla were noted to show greater contrast enhancement than the cortex, with a maximum enhancing effect between 5 and 15 minutes. Using doses of 1.0 and 2.5 mmol/kg, more than 100 per cent increases in spin echo intensities above the baseline were observed. The lowest tested dose of 0.1 mmol/kg showed an easily detectable enhancing effect for NAT. The good contrast enhancing properties of NAT, considered together with its better acute tolerance, justifies further investigation of this non-ionic compound.
W Grodd; H Paajanen; U G Eriksson; D Revel; F Terrier; R C Brasch
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  28     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:    1987 Sep-Oct
Date Detail:
Created Date:  1988-01-19     Completed Date:  1988-01-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  593-600     Citation Subset:  IM    
Medizinisches Strahleninstitut, Universität Tübingen, West Germany.
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MeSH Terms
Cyclic N-Oxides / diagnostic use*
Kidney / anatomy & histology*
Kidney Cortex / analysis
Kidney Medulla / analysis
Magnetic Resonance Imaging / methods*
Rats, Inbred Strains
Spin Labels*
Grant Support
Reg. No./Substance:
0/Cyclic N-Oxides; 0/Spin Labels; 2154-68-9/2,2,5,5-tetramethyl-1-pyrrolidinyloxy-3-carboxylic acid; 97546-74-2/N-1-hydroxymethyl-2,3-dihydroxypropyl-2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-carboxamide

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