Document Detail

Comparison of intravaginal and two intracervical prostaglandin E2 gels in pre-induction of labour.
MedLine Citation:
PMID:  8092777     Owner:  NLM     Status:  MEDLINE    
A randomized study was undertaken to compare the effect of vaginal (1 mg of dinoprostone/2.5 ml gel) and intracervical (0.5 mg of dinoprostone in 2.5 ml of two different vehicles) on induction of labor and perinatal outcome. Sixty women (n = 20/20/20) who presented with an unfavorable cervix and a specific indication for the induction of labor participated in the study. There were no significant differences between the groups with respect to maternal age, weight, parity, gestational length or Bishop scores before prostaglandin E2 preinduction. Labour was induced with prostaglandin gel alone in twenty-two patients and with oxytocin infusion on the following morning after gel application in seven patients; altogether the rate of successful induction was 48.3%. The rate of uterine hyperstimulation was 16.7% with most cases in the groups receiving intracervical prostaglandin E2. Neonatal asphyxia diagnosed with umbilical vein and artery blood gas analysis was seen in eleven neonates who were delivered by labor induced with prostaglandin gel alone (50%). Prostaglandin pre-induction decreases the need for Cesarean sections in complicated pregnancies, but because of the risk of uterine hyperstimulation and neonatal asphyxia prostaglandins should be used only with specific indications.
U Ekblad; R Erkkola; J Pirhonen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annales chirurgiae et gynaecologiae. Supplementum     Volume:  208     ISSN:  0355-9874     ISO Abbreviation:  Ann Chir Gynaecol Suppl     Publication Date:  1994  
Date Detail:
Created Date:  1994-10-19     Completed Date:  1994-10-19     Revised Date:  2008-02-26    
Medline Journal Info:
Nlm Unique ID:  7702959     Medline TA:  Ann Chir Gynaecol Suppl     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  64-7     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Turku University Central Hospital, Finland.
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MeSH Terms
Administration, Intravaginal
Asphyxia Neonatorum / chemically induced
Cervix Uteri / drug effects
Dinoprostone / administration & dosage*,  adverse effects
Extraction, Obstetrical
Fetal Distress / chemically induced
Infant, Newborn
Labor, Induced / methods*
Pregnancy Complications / etiology,  therapy*
Uterine Contraction / drug effects
Reg. No./Substance:
0/Gels; 363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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