Document Detail

Comparison of intrauterine hematologic and biochemical values between twin pairs with and without stuck twin syndrome.
MedLine Citation:
PMID:  7755045     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to compare hematologic and biochemical values in cordocentesis specimens from twin pairs with and without stuck twin syndrome. STUDY DESIGN: Cordocentesis was performed on 38 twin pairs. Assignment to the stuck twin syndrome group (n = 8) was based on ultrasonographic findings of discordant size and amniotic fluid volume, concordant gender, and a single placenta. A receiver-operator characteristic curve was constructed with the use of intertwin hemoglobin differences. For the stuck twin syndrome group regression analysis of gestational age and intertwin hemoglobin difference was done. RESULTS: We found significant (p = 0.03) intertwin differences in hemoglobin between the stuck twin syndrome group (mean 5.35 gm/dl, range 0.5 to 15.4 gm/dl) and the comparison group (mean 0.10 gm/dl, range 0.0 to 2.4 gm/dl). A nearly significant relationship between gestational age and intertwin hemoglobin difference was noted in the stuck twin syndrome group. When the hemoglobin difference was > 2.4 gm/dl, all cases had stuck twin syndrome (sensitivity = 50%, specificity = 100%, positive predictive value = 100%, negative predictive value = 91%). In the stuck twin syndrome group there was a trend toward larger intertwin differences in albumin and total protein. Intertwin blood gas values between the groups did not differ, but the average PO2 was lower when the smaller twins of the two groups were compared. CONCLUSION: An intertwin difference in hemoglobin > 2.4 gm/dl is consistent with stuck twin syndrome. Large intertwin hemoglobin differences and imbalances in albumin and total protein may be seen in stuck twin syndrome.
S M Berry; K S Puder; S F Bottoms; J E Uckele; R Romero; D B Cotton
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  172     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-19     Completed Date:  1995-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1403-10     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Wayne State University/Hutzel Hospital, Detroit, MI 48201, USA.
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MeSH Terms
Blood Chemical Analysis
Blood Proteins / metabolism
False Positive Reactions
Fetal Diseases / blood*
Fetofetal Transfusion / blood*
Fetus / metabolism*
Gestational Age
Hemoglobins / metabolism*
Oxygen / blood
Predictive Value of Tests
ROC Curve
Regression Analysis
Retrospective Studies
Sensitivity and Specificity
Serum Albumin / metabolism
Reg. No./Substance:
0/Blood Proteins; 0/Hemoglobins; 0/Serum Albumin; 7782-44-7/Oxygen

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