Document Detail

Comparison of intrafollicular sperm injection and intrauterine insemination in the treatment of subfertility.
MedLine Citation:
PMID:  22832940     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare the efficacy of intrafollicular sperm injection (IFI) versus intrauterine insemination (IUI) in the treatment of subfertility.
METHODS: 38 couples suffering primary or secondary subfertility contributed a total of 47 IUI or IFI cycles, 26 by IUI and 21 by IFI. Folliculogenesis, ovulation triggering, and IUI or IFI were performed. Motile spermatozoa were inseminated into the uterine cavity for IUI or injected into pre-ovulatory follicles for IFI. The rate of biochemical and clinical pregnancy was assessed.
RESULTS: The rate of biochemical pregnancy/cycle for IUI was 11 % as compared to 38 % for IFI (p = 0.04). The rate of clinical pregnancy/cycle for IUI was 11 % as compared to 29 % for IFI (p = 0.26). The rate of twin pregnancy and miscarriage was low and no high order multiple gestation was observed. The rate of ectopic tubal pregnancy/cycle for IUI was 0 % as compared to 9 % for IFI (p = 0.19); no ovarian pregnancy was observed. When the analysis was confined to IFI cycles in which 2.68-6.65 million motile spermatozoa were injected/follicle (n = 10), a rate of 60 % clinical pregnancy/cycle was observed, of which 2 were ectopic.
CONCLUSION: Under the conditions described herein, IFI was more effective than IUI at achieving pregnancy.
Caterina Lucchini; Emanuele Volpe; Angelo Tocci
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article     Date:  2012-07-26
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-05-03     Revised Date:  2013-10-10    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1103-9     Citation Subset:  IM    
Gruppo Donnamed, Reproductive Medicine Unit, Nuova Villa Claudia Clinic, Via Flaminia Nuova 280, Rome, Italy.
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MeSH Terms
Fertilization in Vitro
Infertility / therapy*
Insemination, Artificial / methods*
Ovarian Follicle
Pregnancy Outcome*
Pregnancy Rate
Pregnancy, Twin
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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