Document Detail


Comparison of initial intraocular pressure response with topical beta-adrenergic antagonists and prostaglandin analogues in African American and white individuals in the Ocular Hypertension Treatment Study.
MedLine Citation:
PMID:  17420364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare the intraocular pressure (IOP) responses of self-identified African American and white participants in the Ocular Hypertension Treatment Study to therapeutic trials of topical, nonselective beta-adrenergic antagonists or prostaglandin analogues. METHODS: Multivariate models that adjusted for baseline IOP and corneal thickness were used to estimate IOP response by race. Participants included 536 who were prescribed topical beta-adrenergic antagonists and 191 who were prescribed prostaglandin analogues, 25% of whom were African American. MAIN OUTCOME MEASURE: Intraocular pressure response in the ipsilateral eye after 4 to 6 weeks of a therapeutic trial. RESULTS: Intraocular pressure response to nonselective beta-adrenergic antagonists did not differ between African American and white participants. Intraocular pressure response to prostaglandin analogues was slightly greater in African American participants, but this difference was not statistically significant. With both classes of medication, greater IOP reduction was associated with higher baseline IOP and thinner central corneal measurement. CONCLUSIONS: We found no statistically significant differences in IOP response to topical, nonselective beta-adrenergic antagonists or prostaglandin analogues between self-identified African American and white individuals. Application to Clinical Practice Studies of IOP response to medication should statistically adjust for baseline IOP and central corneal thickness. Clinicians should consider factors other than ethnicity when choosing an ocular hypotensive medication for a patient. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00000125.
Authors:
Steven L Mansberger; Bret A Hughes; Mae O Gordon; Steven D Spaner; Julia A Beiser; George A Cioffi; Michael A Kass;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  125     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-10     Completed Date:  2007-05-03     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  454-9     Citation Subset:  AIM; IM    
Affiliation:
Devers Eye Institute/Discoveries in Sight, Legacy Health System, Portland, Ore, USA.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00000125
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adrenergic beta-Antagonists / administration & dosage*
Adult
African Americans*
Aged
Aged, 80 and over
European Continental Ancestry Group*
Female
Glaucoma, Open-Angle / ethnology,  prevention & control
Humans
Intraocular Pressure / drug effects*
Male
Middle Aged
Ocular Hypertension / drug therapy*,  ethnology*
Ophthalmic Solutions / administration & dosage
Prostaglandins F, Synthetic / administration & dosage*
Tonometry, Ocular
Grant Support
ID/Acronym/Agency:
EY09307/EY/NEI NIH HHS; EY09341/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Ophthalmic Solutions; 0/Prostaglandins F, Synthetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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