Document Detail

Comparison of inhaled salbutamol powder and aerosol in asthmatic patients with low peak expiratory flow level.
MedLine Citation:
PMID:  3987769     Owner:  NLM     Status:  MEDLINE    
The short-term bronchodilator effects of dry salbutamol powder and a pressurized salbutamol aerosol were compared in 22 patients with severe asthma, on 3 consecutive mornings, in a double-dummy cross-over study. Only patients with peak expiratory flow (PEF) rate lower than 250 l/min, were recruited. PEF measurement was employed to assess changes in ventilatory function induced by inhalation of the drugs. No significant difference was found between the PEF changes induced by the dry salbutamol powder (400 micrograms) and the pressurized aerosol (200 micrograms). Both forms of the drug produced a significant rise in mean PEF values. The study shows that even in asthmatic patients with poor ventilation, a dry powder inhaler and pressurized aerosol are effective means of drug delivery to the lungs.
H Tukiainen; E O Terho
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  27     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-06-03     Completed Date:  1985-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  645-7     Citation Subset:  IM    
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MeSH Terms
Albuterol / administration & dosage,  adverse effects,  therapeutic use*
Asthma / drug therapy*,  physiopathology
Middle Aged
Peak Expiratory Flow Rate
Time Factors
Reg. No./Substance:
0/Aerosols; 0/Powders; 18559-94-9/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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