Document Detail


Comparison of inhaled salbutamol powder and aerosol in asthmatic patients with low peak expiratory flow level.
MedLine Citation:
PMID:  3987769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The short-term bronchodilator effects of dry salbutamol powder and a pressurized salbutamol aerosol were compared in 22 patients with severe asthma, on 3 consecutive mornings, in a double-dummy cross-over study. Only patients with peak expiratory flow (PEF) rate lower than 250 l/min, were recruited. PEF measurement was employed to assess changes in ventilatory function induced by inhalation of the drugs. No significant difference was found between the PEF changes induced by the dry salbutamol powder (400 micrograms) and the pressurized aerosol (200 micrograms). Both forms of the drug produced a significant rise in mean PEF values. The study shows that even in asthmatic patients with poor ventilation, a dry powder inhaler and pressurized aerosol are effective means of drug delivery to the lungs.
Authors:
H Tukiainen; E O Terho
Related Documents :
10776429 - Positive end-expiratory pressure and response to inhaled nitric oxide: changing nonresp...
7005679 - Influence of positive end-expiratory pressure on left ventricular performance.
8082379 - A functional and morphologic analysis of pressure-controlled inverse ratio ventilation ...
18641799 - The effects of positive end-expiratory pressure in alveolar recruitment during mechanic...
9619219 - The effect of intraoperative ventilation strategies on perioperative atelectasis.
1519849 - Adaptations of the peripheral circulation to peep.
7365419 - The effects of extracts from neurosecretory cells in the anterior vena cava and pharyng...
24949249 - How male sound pressure level influences phonotaxis in virgin female jamaican field cri...
7065419 - Regional differences in capillary density and myocyte size in the normal human heart.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  27     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-06-03     Completed Date:  1985-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  645-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aerosols
Albuterol / administration & dosage,  adverse effects,  therapeutic use*
Asthma / drug therapy*,  physiopathology
Female
Humans
Male
Middle Aged
Peak Expiratory Flow Rate
Powders
Time Factors
Chemical
Reg. No./Substance:
0/Aerosols; 0/Powders; 18559-94-9/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pharmacokinetics and metabolism of isosorbide-dinitrate after intravenous and oral administration.
Next Document:  Drug binding in the undernourished: a study of the binding of propranolol to alpha 1-acid glycoprote...