Document Detail

Comparison of inhalation inductions with xenon and sevoflurane.
MedLine Citation:
PMID:  9366936     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Xenon is an odorless gas with low blood-gas solubility coefficient and without occupational and environmental hazards. This investigation was performed to evaluate the speed of induction, and respiratory and cardiovascular reactions to inhalation induction with xenon compared to an equianesthetic concentration of sevoflurane. METHOD: Twenty-four adult ASA 1-2 patients premedicated with 0.05 mg/kg of midazolam were instructed to take vital capacity breaths of 1 minimum alveolar concentration (MAC) of either xenon or sevoflurane until they lost consciousness. Induction time, total ventilatory volume, tidal volume, respiratory rate, minute ventilation, end-tidal MAC fraction, cardiovascular parameters and oxygen saturation were recorded. The patients were interviewed on the following day to evaluate their acceptability rating of the inhalation inductions. RESULTS: Compared to equianesthetic sevoflurane, xenon produced a faster induction of anesthesia (147 +/- 59 versus 71 +/- 21 s, respectively) with smaller decreases in respiratory rate, tidal volume and minute ventilation. Both agents showed comparable cardiovascular stability and oxygen saturation during induction. One patient in the sevoflurane group had breath-holding and movements of extremities and another had only breath-holding. No patients in the xenon group experienced any complications. CONCLUSION: Xenon produced a faster induction of anesthesia without any complications than sevoflurane. Xenon had smaller decreases in tidal volume and respiratory rate during induction than sevoflurane. Xenon might offer an alternative to sevoflurane for an inhalation induction.
Y Nakata; T Goto; S Morita
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  41     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-18     Completed Date:  1997-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1157-61     Citation Subset:  IM    
Department of Anesthesia, Teikyo University School of Medicine Ichihara Hospital, Chiba, Japan.
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MeSH Terms
Anesthesia, Inhalation*
Anesthetics, Inhalation*
Blood Pressure / drug effects
Double-Blind Method
Heart Rate / drug effects
Methyl Ethers*
Respiratory System / drug effects
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Ethers; 0/Methyl Ethers; 28523-86-6/sevoflurane; 7440-63-3/Xenon

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