Document Detail

Comparison of infusions of alfentanil or pethidine for sedation of ventilated patients on the ITU.
MedLine Citation:
PMID:  2876719     Owner:  NLM     Status:  MEDLINE    
Sedation was studied in 30 patients requiring overnight ventilation in the intensive therapy unit (ITU). Patients received an infusion of either alfentanil or pethidine, supplemented with midazolam. The infusion rates were adjusted to provide optimal sedation as judged by a nurse, and measurements were made of quality of sedation, recovery and serum cortisol concentration. In addition, blood concentrations of alfentanil were measured to permit pharmacokinetic and pharmacodynamic analysis. Satisfactory sedation was achieved in both groups. The required infusion rate for alfentanil was between 0.4 and 0.5 micrograms kg-1 min-1. Recovery was good in both groups, apart from one patient in the alfentanil group, in whom recovery was greatly prolonged and alfentanil pharmacokinetics were abnormal. A difference was found in the metabolic response to surgery between the two groups, the response in the alfentanil group being significantly less marked.
P M Yate; D Thomas; S M Short; P S Sebel; J Morton
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  58     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-12-17     Completed Date:  1986-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1091-9     Citation Subset:  IM    
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MeSH Terms
Analgesics, Opioid / administration & dosage*
Critical Care
Fentanyl / administration & dosage,  analogs & derivatives*,  blood
Hydrocortisone / blood
Hypnotics and Sedatives*
Meperidine / administration & dosage*
Middle Aged
Respiration, Artificial*
Reg. No./Substance:
0/Analgesics, Opioid; 0/Hypnotics and Sedatives; 437-38-7/Fentanyl; 50-23-7/Hydrocortisone; 57-42-1/Meperidine; 71195-58-9/Alfentanil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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