| Comparison of infusions of alfentanil or pethidine for sedation of ventilated patients on the ITU. | |
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MedLine Citation:
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PMID: 2876719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sedation was studied in 30 patients requiring overnight ventilation in the intensive therapy unit (ITU). Patients received an infusion of either alfentanil or pethidine, supplemented with midazolam. The infusion rates were adjusted to provide optimal sedation as judged by a nurse, and measurements were made of quality of sedation, recovery and serum cortisol concentration. In addition, blood concentrations of alfentanil were measured to permit pharmacokinetic and pharmacodynamic analysis. Satisfactory sedation was achieved in both groups. The required infusion rate for alfentanil was between 0.4 and 0.5 micrograms kg-1 min-1. Recovery was good in both groups, apart from one patient in the alfentanil group, in whom recovery was greatly prolonged and alfentanil pharmacokinetics were abnormal. A difference was found in the metabolic response to surgery between the two groups, the response in the alfentanil group being significantly less marked. |
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Authors:
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P M Yate; D Thomas; S M Short; P S Sebel; J Morton |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of anaesthesia Volume: 58 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-12-17 Completed Date: 1986-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1091-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alfentanil Analgesics, Opioid / administration & dosage* Critical Care Female Fentanyl / administration & dosage, analogs & derivatives*, blood Humans Hydrocortisone / blood Hypnotics and Sedatives* Kinetics Male Meperidine / administration & dosage* Middle Aged Respiration, Artificial* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Hypnotics and Sedatives; 437-38-7/Fentanyl; 50-23-7/Hydrocortisone; 57-42-1/Meperidine; 71195-58-9/Alfentanil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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