Document Detail

Comparison of infarct size produced by coronary artery occlusion in purebred beagle and mixed-breed dogs.
MedLine Citation:
PMID:  6616328     Owner:  NLM     Status:  MEDLINE    
This investigation demonstrated a significant difference in infarct size following coronary artery occlusion between purebred beagles and mixed-breed dogs. Myocardial infarctions were produced by a two-stage ligation of the left anterior descending artery (LAD). Myocardial infarct size, expressed as percent of left ventricular mass, was determined at 24 h by nitro blue tetrazolium staining. Infarct size was significantly smaller (12.5 +/- 3.4%) and more variable (coefficient of variation 72%) in beagles than in mixed-breed animals (28.0 +/- 2.4% infarct size, 23% coefficient of variation) (p less than 0.001). Ectopic activity at 24 h was similar for both beagles and mixed breed, 92 +/- 7 and 92 +/- 2% of total heart rate, respectively. Thus this study indicates that the breed of dog (i.e., purebred beagles versus mixed-breed animals) can be an important variable in the study of infarct size resulting from coronary artery occlusion.
W E Burmeister; R D Reynolds
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  61     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  672-5     Citation Subset:  IM    
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MeSH Terms
Disease Models, Animal
Heart Rate
Myocardial Infarction / pathology*
Species Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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