| Comparison of detomidine/ketamine and guaiphenesin/thiopentone for induction of anaesthesia in horses maintained with halothane. | |
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MedLine Citation:
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PMID: 9637380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This prospective clinical study compared the physiological effects of two commonly used anaesthetic induction techniques in horses maintained with halothane. One hundred horses admitted for elective surgery were randomly allocated to receive either guaiphenesin (to effect) and thiopentone (5 mg/kg), or detomidine (20 microg/kg) and ketamine (2 mg/kg) for the induction of anaesthesia after acepromazine premedication. Anaesthesia was maintained with halothane in oxygen. There were no significant differences in breed, age, sex, weight, type of surgery and duration of anaesthesia between the groups. Immediately after induction of anaesthesia heart rate was higher after guaiphenesin and thiopentone, and arterial blood pressure was higher after detomidine and ketamine. Thereafter hypotension, often necessitating an infusion of dobutamine, developed in both groups. Arterial blood gases and respiratory rates were similar in the two groups. There were no significant differences between the groups in the subjectively scored quality of induction and recovery, or in recovery time. |
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Authors:
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R C Bennett; P M Taylor; J C Brearley; C B Johnson; S P Luna |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Veterinary record Volume: 142 ISSN: 0042-4900 ISO Abbreviation: Vet. Rec. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-08-21 Completed Date: 1998-08-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0031164 Medline TA: Vet Rec Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 541-5 Citation Subset: IM |
Affiliation:
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Animal Health Trust, Newmarket, Suffolk. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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administration & dosage* Anesthesia, General / veterinary* Anesthetics, Dissociative / administration & dosage* Anesthetics, Inhalation / administration & dosage* Anesthetics, Intravenous / administration & dosage* Animals Blood Pressure Drug Therapy, Combination Expectorants / administration & dosage* Female Guaifenesin* Halothane* Heart Rate Horses* / surgery Imidazoles* Ketamine* Male Prospective Studies Surgical Procedures, Operative / veterinary Thiopental* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Anesthetics, Dissociative; 0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Expectorants; 0/Imidazoles; 151-67-7/Halothane; 6740-88-1/Ketamine; 76-75-5/Thiopental; 76631-46-4/detomidine; 93-14-1/Guaifenesin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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