Document Detail

Comparison of the incidence of imidapril and enalapril induced cough.
MedLine Citation:
PMID:  20364557     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Imidapril is an angiotensin converting enzyme (ACE) inhibitor without a sulfhydril group which has been shown from previous study to have low incidence of ACE inhibitor induced cough. OBJECTIVE: To compare the incidence of cough between two ACE inhibitors, imidapril and enalapril. MATERIAL AND METHOD: A comparative cross over study was performed in 119 patients with hypertension or left ventricular dysfunction. Patients were assigned to one of the two treatment groups, either a group receiving imidapril or enalapril for 4 weeks (Period I) and then these same groups were crossed over to receive either enalapril or imidapril for 4 weeks (Period II). The occurrence of cough during treatment was monitored by interviewing the patients. RESULTS: The incidence of cough was 44 % while on imidapril treatment and 66% while on enalapril treatment (p = 0.0014). The antihypertensive effects of two drugs were not different. CONCLUSION: The incidence of cough was significantly less under imidapril than under enalapril treatment, while there was no difference in the antihypertensive effects between the two ACE inhibitors.
Warangkna Boonyapisit; Damras Tresukosol
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  93 Suppl 1     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-04-06     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  S48-53     Citation Subset:  IM    
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Administration, Oral
Angiotensin-Converting Enzyme Inhibitors / pharmacology*,  therapeutic use
Cough / chemically induced*
Cross-Over Studies
Enalapril / pharmacology*,  therapeutic use
Hypertension / drug therapy*,  epidemiology
Imidazolidines / pharmacology*,  therapeutic use
Middle Aged
Treatment Outcome
Ventricular Dysfunction, Left / drug therapy*,  epidemiology
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Imidazolidines; 75847-73-3/Enalapril; 89396-94-1/imidapril

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