| Comparison of the incidence of imidapril and enalapril induced cough. | |
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MedLine Citation:
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PMID: 20364557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Imidapril is an angiotensin converting enzyme (ACE) inhibitor without a sulfhydril group which has been shown from previous study to have low incidence of ACE inhibitor induced cough. OBJECTIVE: To compare the incidence of cough between two ACE inhibitors, imidapril and enalapril. MATERIAL AND METHOD: A comparative cross over study was performed in 119 patients with hypertension or left ventricular dysfunction. Patients were assigned to one of the two treatment groups, either a group receiving imidapril or enalapril for 4 weeks (Period I) and then these same groups were crossed over to receive either enalapril or imidapril for 4 weeks (Period II). The occurrence of cough during treatment was monitored by interviewing the patients. RESULTS: The incidence of cough was 44 % while on imidapril treatment and 66% while on enalapril treatment (p = 0.0014). The antihypertensive effects of two drugs were not different. CONCLUSION: The incidence of cough was significantly less under imidapril than under enalapril treatment, while there was no difference in the antihypertensive effects between the two ACE inhibitors. |
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Authors:
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Warangkna Boonyapisit; Damras Tresukosol |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 93 Suppl 1 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-04-06 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: Thailand |
Other Details:
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Languages: eng Pagination: S48-53 Citation Subset: IM |
Affiliation:
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Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. waran_byps@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aged Angiotensin-Converting Enzyme Inhibitors / pharmacology*, therapeutic use Cough / chemically induced* Cross-Over Studies Enalapril / pharmacology*, therapeutic use Female Humans Hypertension / drug therapy*, epidemiology Imidazolidines / pharmacology*, therapeutic use Incidence Male Middle Aged Treatment Outcome Ventricular Dysfunction, Left / drug therapy*, epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Imidazolidines; 75847-73-3/Enalapril; 89396-94-1/imidapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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