Document Detail


Comparison of in vivo acute stent recoil between the bioabsorbable everolimus-eluting coronary stent and the everolimus-eluting cobalt chromium coronary stent: insights from the ABSORB and SPIRIT trials.
MedLine Citation:
PMID:  17503509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study sought to evaluate and compare in vivo acute stent recoil of a novel bioabsorbable stent and a metallic stent. BACKGROUND: The bioabsorbable everolimus-eluting coronary stent (BVS) is composed of a poly-L-lactic acid backbone, coated with a bioabsorbable polymer containing the antiproliferative drug, everolimus, and expected to be totally metabolized and absorbed in the human body. Because the BVS is made from polymer, it may have more acute recoil than metallic stents in vivo. METHODS: A total of 54 patients, who underwent elective stent implantation for single de novo native coronary artery lesions, were enrolled: 27 patients treated with the BVS and 27 patients treated with the everolimus-eluting cobalt chromium stent (EES). Acute absolute recoil, assessed by quantitative coronary angiography, was defined as the difference between mean diameter of the last inflated balloon at the highest pressure (X) and mean lumen diameter of the stent immediately after the last balloon deflation (Y). Acute percent recoil was defined as (X - Y)/X and expressed as a percentage. RESULTS: Acute absolute recoil of the BVS and EES was 0.20 +/- 0.21 mm and 0.13 +/- 0.21 mm, respectively (P = 0.32). Acute percent recoil was 6.9% +/- 7.0% in the BVS group and 4.3% +/- 7.1% in the EES group (P = 0.25). CONCLUSIONS: In vivo acute stent recoil of the BVS is slightly larger but insignificantly different from that of the EES, implying that the BVS may have good radial strength similar to the metallic stent.
Authors:
Shuzou Tanimoto; Patrick W Serruys; Leif Thuesen; Dariusz Dudek; Bernard de Bruyne; Bernard Chevalier; John A Ormiston
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  70     ISSN:  1522-1946     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-02     Completed Date:  2008-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-23     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Affiliation:
Department of Interventional Cardiology, Thorax Center, Erasmus MC, Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Transluminal, Percutaneous Coronary / instrumentation*
Biocompatible Materials*
Biomechanics
Cardiovascular Agents / administration & dosage*
Chromium Alloys / chemistry*
Clinical Trials as Topic
Coronary Angiography
Coronary Artery Disease / radiography,  therapy*
Drug-Eluting Stents*
Female
Humans
Lactic Acid / chemistry*
Male
Middle Aged
Polymers / chemistry*
Prosthesis Design
Research Design
Sirolimus / administration & dosage,  analogs & derivatives*
Tomography, Optical Coherence
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Cardiovascular Agents; 0/Chromium Alloys; 0/Polymers; 159351-69-6/everolimus; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid; 53123-88-9/Sirolimus
Comments/Corrections
Comment In:
Catheter Cardiovasc Interv. 2007 Oct 1;70(4):524   [PMID:  17896407 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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