Document Detail

Comparison of in vitro jejunal uptake of L-valine and L-lysine in the rat during maturation.
MedLine Citation:
PMID:  3934359     Owner:  NLM     Status:  MEDLINE    
The maturational characteristics and patterns of absorption of the neutral amino acid L-valine were compared with those of the basic amino acid L-lysine using in vitro preparations of everted sacs obtained from the jejunum of suckling (2 weeks old), weanling (3 weeks old), and adolescent (6 weeks old) rats. Absorption rates determined as net transport into sac fluid and mucosal uptake (mumol/h/g protein or weight of mucosal scrapings) for both valine and lysine were greater in the suckling than in the weanling or adolescent rats. This appeared to be true for both the carrier-mediated and the diffusive processes for absorption, determined from the relationship between the observed absorption rates and the corresponding mucosal incubation medium amino acid concentrations. The major decline in rate of absorption occurred before the period of weaning. Between the period of suckling and adolescence the carrier-mediated absorption decreased by 55% for valine and by 90% for lysine, suggesting that during maturation of the jejunum the number of the carrier macromolecules responsible for absorption of valine and lysine per unit protein or weight of mucosa decreases with increasing age.
M K Younoszai; C Smith; M H Finch
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  4     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-01-22     Completed Date:  1986-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  992-7     Citation Subset:  IM    
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MeSH Terms
Age Factors
Animals, Suckling
Biological Transport, Active
Intestinal Absorption
Intestinal Mucosa / metabolism
Jejunum / growth & development,  metabolism*
Lysine / metabolism*
Rats, Inbred Strains
Valine / metabolism*
Reg. No./Substance:
56-87-1/Lysine; 7004-03-7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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