Document Detail


Comparison of the in vitro hemodynamic performance of new flow diverters for bypass of brain aneurysms.
MedLine Citation:
PMID:  22938365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One possible treatment for cerebral aneurysms is a porous tubular structure, similar to a stent, called a flow diverter. A flow diverter can be placed across the neck of a cerebral aneurysm to induce the cessation of flow and initiate the formation of an intra-aneurysmal thrombus. This excludes the aneurysm from the parent artery and returns the flow of blood to normal. Previous flow diverting devices have been analyzed to determine optimal characteristics, such as braiding angle and wire diameter. From this information, a new optimized device was designed to achieve equivalent hemodynamic performance to the previous best device, but with better longitudinal flexibility to preserve physiological arterial configuration. The new device was tested in vitro in an elastomeric replica of the rabbit elastase induced aneurysm model and is now in the process of being tested in vivo. Particle image velocimetry was utilized to determine the velocity field in the plane of symmetry of the model under pulsatile flow conditions. Device hemodynamic performance indices such as the hydrodynamic circulation were evaluated from the velocity fields. Comparison of these indices with the previous best device and a control shows that the significant design changes of the device did not change its hemodynamic attributes (p > 0.05).
Authors:
Asher L Trager; Chander Sadasivan; Baruch B Lieber
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  134     ISSN:  1528-8951     ISO Abbreviation:  J Biomech Eng     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-09-03     Completed Date:  2013-04-23     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  084505     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Elasticity
Hemodynamics*
Intracranial Aneurysm / physiopathology*,  surgery*
Porosity
Rabbits
Vascular Grafting / instrumentation*
Grant Support
ID/Acronym/Agency:
R01 NS045753/NS/NINDS NIH HHS; R01 NS045753-05A1/NS/NINDS NIH HHS; R01-NS045753/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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