Document Detail


Comparison of the in vitro drug sensitivity of Trypanosoma brucei gambiense strains from West and Central Africa isolated in the periods 1960-1995 and 1999-2004.
MedLine Citation:
PMID:  17078916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The situation of human African trypanosomiasis remains serious with one of the main threats being the increasing number of relapses or treatment failures after melarsoprol treatment. In order to investigate and to compare drug sensitivities of trypanosomes isolated at different time periods and in different locations, two sets of Trypanosoma brucei gambiense strains were used. One set was isolated in the time period 1960-1981 and the other one in 1995-2004 from different locations of West and Central Africa. These isolates were not selected based on the treatment outcome but on availability. The drug sensitivity profile for all available drugs in use and the diamidine compound DB75 was established. IC(50) values were not significantly different between the "old" and "new" stocks. No indications for emerging drug resistance to any drug could be observed. The results indicate a relative stability of in vitro sensitivity of T. b. gambiense to trypanocidal drugs in space (West and Central Africa) and time (1960-2004).
Authors:
A C Lékané Likeufack; R Brun; A Fomena; P Truc
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-31
Journal Detail:
Title:  Acta tropica     Volume:  100     ISSN:  0001-706X     ISO Abbreviation:  Acta Trop.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370374     Medline TA:  Acta Trop     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Affiliation:
Organisation de Coordination pour la Lutte Contre les Endémies en Afrique Centrale, Yaoundé, Cameroon.
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MeSH Terms
Descriptor/Qualifier:
Africa, Central / epidemiology
Africa, Western / epidemiology
Animals
Humans
Inhibitory Concentration 50
Melarsoprol / pharmacology*
Parasitic Sensitivity Tests
Time Factors
Trypanocidal Agents / pharmacology*
Trypanosoma brucei gambiense / classification,  drug effects*,  isolation & purification
Trypanosomiasis, African / epidemiology,  parasitology
Chemical
Reg. No./Substance:
0/Trypanocidal Agents; 494-79-1/Melarsoprol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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