Document Detail


Comparison of human infants and rhesus monkeys on Piaget's AB task: evidence for dependence on dorsolateral prefrontal cortex.
MedLine Citation:
PMID:  2924839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper reports evidence linking dorsolateral prefrontal cortex with one of the cognitive abilities that emerge between 7.5-12 months in the human infant. The task used was Piaget's Stage IV Object Permanence Test, known as AB (pronounced "A not B"). The AB task was administered (a) to human infants who were followed longitudinally and (b) to intact and operated adult rhesus monkeys with bilateral prefrontal and parietal lesions. Human infants displayed a clear developmental progression in AB performance, i.e., the length of delay required to elicit the AB error pattern increased from 2-5 s at 7.5-9 months to over 10 s at 12 months of age. Monkeys with bilateral ablations of dorsolateral prefrontal cortex performed on the AB task as did human infants of 7.5-9 months; i.e., they showed the AB error pattern at delays of 2-5 s and chance performance at 10 s. Unoperated and parietally operated monkeys succeeded at delays of 2, 5, and 10 s; as did 12 month old human infants. AB bears a striking resemblance to Delayed Response, the classic test for dorsolateral prefrontal function in the rhesus monkey, and indeed performance on AB and Delayed Response in the same animals in the present study was fully comparable. These findings provide direct evidence that AB performance depends upon dorsolateral prefrontal cortex in rhesus monkeys and indicates that maturation of dorsolateral prefrontal cortex may underlie the developmental improvement in AB performance of human infants from 7.5-12 months of age. This improvement marks the development of the ability to hold a goal in mind in the absence of external cues, and to use that remembered goal to guide behavior despite the pull of previous reinforcement to act otherwise. This confers flexibility and freedom to choose and control what one does.
Authors:
A Diamond; P S Goldman-Rakic
Related Documents :
9519239 - Growth and reproduction in captive tufted capuchins (cebus apella).
11217219 - The relationship between size and fecundity in aedes albopictus.
11209889 - Indirect partner choice through manipulation of male behaviour by female fowl, gallus g...
12891509 - Clinical management and molecular cytogenetic characterization in a 45,x/46,x,idic(yp) ...
18177329 - Sex-related effects of maternal egg investment on offspring in relation to carotenoid a...
21499959 - Interactive magnetic resonance voiding cystourethrography (imrvc) for vesicoureteric re...
9720829 - Indications for caesarean section in breech presentation.
24362929 - Noninvasive monitoring of gas in the lungs and intestines of newborn infants using diod...
15690369 - Neonatal phenotype in kabuki syndrome.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental brain research     Volume:  74     ISSN:  0014-4819     ISO Abbreviation:  Exp Brain Res     Publication Date:  1989  
Date Detail:
Created Date:  1989-04-24     Completed Date:  1989-04-24     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  24-40     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Cognition / physiology*
Female
Frontal Lobe / growth & development*,  physiology
Humans
Infant
Longitudinal Studies
Macaca / growth & development*
Macaca mulatta / growth & development*,  physiology
Male
Reaction Time / physiology
Sex Factors
Grant Support
ID/Acronym/Agency:
HD-10094/HD/NICHD NIH HHS; MH-00298/MH/NIMH NIH HHS; MH-38456/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Note on the tonotopic organization in the cat medial geniculate body: influence of sampling of units...
Next Document:  Postural synergies in axial movements: short and long-term adaptation.