Document Detail

Comparison of human exposures to selected chemicals with thresholds from NTP carcinogenicity studies in rodents.
MedLine Citation:
PMID:  14580010     Owner:  NLM     Status:  MEDLINE    
The National Toxicology Program (NTP) Technical Reports online database was reviewed to find chemicals that were reported to show clear evidence of carcinogenicity in the NTP rodent studies and for which data on human exposure could be found. Six representative compounds were selected. Three volatile compounds: ethyl benzene, perchloroethylene, and methylene chloride; two drugs in current use: phenytoin and primidone; and one naturally occurring, widely used, flavor: allyl isothiocyanate, were selected. The carcinogenicity data from each of the NTP Technical Reports were plotted using the Rozman scale to determine the threshold for carcinogenicity from the rodent studies. The human exposures for each chemical were calculated and compared with that threshold. The thresholds for carcinogenicity of the three volatile compounds were several orders of magnitude above the levels present in ambient air in the USA. The Threshold Limit Value (TLV) of the American Conference of Governmental Industrial Hygienists (ACGIH) for these three compounds varied between several orders of magnitude below the carcinogenicity threshold to being at the threshold. The maximum recommended doses of both drugs were at the carcinogenicity threshold. The estimated mean daily human consumption of the natural flavor was less than 100 x below the carcinogenicity threshold. This method of comparison between human exposure and animal carcinogenicity studies is more objective and informative than those in current use.
William J Waddell
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  22     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-28     Completed Date:  2004-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  501-6     Citation Subset:  IM    
Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
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MeSH Terms
Adenoma / chemically induced
Carcinogenicity Tests*
Carcinogens / toxicity*
Carcinoma / chemically induced
Databases, Factual
Dose-Response Relationship, Drug
Environmental Exposure*
Government Programs
Maximum Allowable Concentration
National Health Programs*
National Institutes of Health (U.S.)
Neoplasms, Experimental / chemically induced
Risk Assessment*
United States
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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