Document Detail

Comparison of hormonal and metabolic markers after a high-fat, Western meal versus a low-fat, high-fiber meal in women with polycystic ovary syndrome.
MedLine Citation:
PMID:  18331737     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effect of meal composition on postprandial T levels in women with polycystic ovary syndrome (PCOS).
DESIGN: Randomized, crossover design.
SETTING: Academic research center.
PATIENT(S): Fifteen women with PCOS.
INTERVENTION(S): We evaluated changes in T, sex hormone binding globulin (SHBG), DHEAS, cortisol, glucose, and insulin for 6 hours after a high-fat, Western meal (HIFAT) (62% fat, 24% carbohydrate, 1 g fiber) and an isocaloric low-fat, high-fiber meal (HIFIB) (6% fat, 81% carbohydrate, 27 g fiber).
MAIN OUTCOME MEASURE(S): Change in T levels.
RESULT(S): Testosterone decreased 27% within 2 hours after both meals. However, T remained below premeal values for 4 hours after the HIFIB meal and 6 hours after the HIFAT meal. Insulin was twofold higher for 2 hours after the HIFIB meal compared with the HIFAT meal. Glucose was higher for 1 hour after the HIFIB meal compared with the HIFAT meal. DHEAS decreased 8%-10% within 2-3 hours after both meals, then increased during the remainder of the study period. Cortisol decreased during the 6-hour period after both meals.
CONCLUSIONS: Diet plays a role in the regulation of T levels in women with PCOS. Further studies are needed to determine the role of diet composition in the treatment of PCOS.
Heather I Katcher; Allen R Kunselman; Romana Dmitrovic; Laurence M Demers; Carol L Gnatuk; Penny M Kris-Etherton; Richard S Legro
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2008-03-10
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-05-01     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1175-82     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood*,  metabolism
Blood Glucose / analysis,  metabolism
Cross-Over Studies
Diet, Atherogenic*
Diet, Fat-Restricted*
Dietary Fats / pharmacology
Dietary Fiber / pharmacology*
Hormones / blood*
Insulin / blood,  metabolism
Polycystic Ovary Syndrome / blood*,  metabolism
Sex Hormone-Binding Globulin / analysis,  metabolism
Testosterone / blood
Western World
Young Adult
Grant Support
#M01RR10732/RR/NCRR NIH HHS; C06 RR016499/RR/NCRR NIH HHS; K24 HD001476/HD/NICHD NIH HHS; K24 HD001476-05/HD/NICHD NIH HHS; K24 HD01476/HD/NICHD NIH HHS; M01 RR010732/RR/NCRR NIH HHS; M01 RR010732-136570/RR/NCRR NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Dietary Fats; 0/Hormones; 0/Insulin; 0/Sex Hormone-Binding Globulin; 3XMK78S47O/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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