| Comparison of histology between recurrent tonsillitis and tonsillar hypertrophy. | |
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MedLine Citation:
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PMID: 12755763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To elucidate the aetiology of tonsillar hypertrophy and recurrent tonsillitis, it is important to determine whether a difference exists between these two conditions in microanatomical architecture. The aim of this study was to investigate the difference in follicle size and numbers in tonsils for patients with tonsillar hypertrophy and recurrent tonsillitis using an image analysis method. Our results showed that there was no significant difference in the mean follicle numbers per counting field (40x magnification) between recurrent tonsillitis (4.5 +/- 2.1) and tonsillar hypertrophy (3.8 +/- 0.5). However, the mean follicle area in the tonsillar hypertrophy group (0.23 +/- 0.02 mm2) is significantly (P < 0.01) larger than in the recurrent tonsillitis group (0.15 +/- 0.02 mm2). Our study demonstrates that tonsillar hypertrophy is characterized histologically by an enlargement of follicles compared with chronic tonsillitis, indicating a hyperplastic condition of lymphoid cells in the germinal centres. It may also explain the difference in aetiology and/or immune defence mechanism underlying these two conditions. |
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Authors:
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P C Zhang; Y T Pang; K S Loh; D Y Wang |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical otolaryngology and allied sciences Volume: 28 ISSN: 0307-7772 ISO Abbreviation: Clin Otolaryngol Allied Sci Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-05-20 Completed Date: 2003-10-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7701793 Medline TA: Clin Otolaryngol Allied Sci Country: England |
Other Details:
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Languages: eng Pagination: 235-9 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, The National University of Singapore, Singapore. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool Humans Hypertrophy Image Processing, Computer-Assisted Palatine Tonsil / pathology* Recurrence Tonsillitis / pathology* |
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