Document Detail

Comparison of a high sensitivity and standard C reactive protein measurement in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis.
MedLine Citation:
PMID:  20498207     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was aimed at comparing high sensitivity C reactive protein (hsCRP) measurement with routine C reactive protein (CRP) evaluation as disease activity parameters in patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nrSpA). METHODS: A total of 269 patients (153 with AS and 116 with nrSpA) were included. Level of hsCRP was measured using particle-enhanced immunoturbidimetric method with the lowest detected level of 0.1 mg/litre. The hsCRP values were compared to results of routine turbidimetric CRP test with the lowest detected level of 6 mg/litre. RESULTS: In the whole group of patients with AS, hsCRP showed a better than routine CRP correlation with clinical parameters. In the whole group of patients with nrSpA, hsCRP correlated with the level of enthesitis-related tenderness only. In the AS subgroup with a negative routine CRP (<6 mg/litre) there was a clear trend for an increased level of pain, stiffness and functional impairment in patients with higher hsCRP concentration. Such a trend was less pronounced in patients with nrSpA. CONCLUSIONS: hsCRP correlates better than routine CRP with clinical disease activity parameters in patients with axial SpA, especially in AS. Therefore, hsCRP could be superior to standard CRP in assessing disease activity in axial SpA.
D A Poddubnyy; M Rudwaleit; J Listing; J Braun; J Sieper
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-05-24
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  69     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  1338-41     Citation Subset:  IM    
Department of Rheumatology, Charité - Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / analysis*
Nephelometry and Turbidimetry / methods
Sensitivity and Specificity
Severity of Illness Index
Spondylarthritis / blood*
Spondylitis, Ankylosing / blood
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

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