| Comparison of the high relaxivity Gd chelates P1152 and Gd-BOPTA for contrast-enhanced MR angiography in rabbits at 1.5 Tesla and 3.0 Tesla. | |
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MedLine Citation:
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PMID: 20677278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare signal-enhancing properties of the high relaxivity Gd chelates P1152 and Gd-BOPTA for contrast-enhanced MR angiography (CE-MRA) in rabbits at 1.5 Tesla (T) and 3.0T. MATERIALS AND METHODS: Three-dimensional CE-MRA of the abdominal vasculature was performed in six rabbits using both contrast agents at a dose of 0.1 mmol/kg. Data acquisition was carried out during first pass and up to 10 min after contrast material administration. CNR was determined in aorta, vena cava, and renal cortex. Image quality (5-point scale, 5 = best) of first pass MR angiograms was rated by two radiologists. RESULTS: During first pass CNR of the aorta was 55.1 +/- 5.8 (P1152) and 40.3 +/- 3.9 (Gd-BOPTA) at 1.5T (P < 0.05), and 114.9 +/- 9.9 (P1152) and 73.5 +/- 8.1 (Gd-BOPTA) at 3.0T (P < 0.05). Both contrast agents showed a comparable decline of CNR within 10 min. Image quality was rated 4.8 +/- 0.40 (P1152) and 4.5 +/- 0.50 (Gd-BOPTA) at 1.5T (P = 0.17), and 4.8 +/- 0.37 (P1152) and 4.7 +/- 0.47 (Gd-BOPTA) at 3.0T (P = 0.61). CONCLUSION: The high relaxivity Gd-chelate P1152 offers potential to improve image contrast for CE-MRA compared with a clinically approved high relaxivity contrast agent. |
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Authors:
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Kersten Peldschus; Mareike Hamdorf; Philippe Robert; Marc Port; Gerhard Adam; Christoph U Herborn |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 459-65 Citation Subset: IM |
Copyright Information:
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2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. k.peldschus@uke.uni-hamburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / pathology Chelating Agents / pharmacology* Contrast Media / pharmacology* Coordination Complexes / pharmacology* Female Image Processing, Computer-Assisted Kidney Cortex / pathology Magnetic Resonance Angiography / methods* Meglumine / analogs & derivatives*, pharmacology Organometallic Compounds / pharmacology* Rabbits Time Factors Vena Cava, Inferior / pathology |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 0/Contrast Media; 0/Coordination Complexes; 0/Organometallic Compounds; 113662-23-0/gadobenic acid; 6284-40-8/Meglumine |
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