Document Detail

Comparison of high and low sodium bicarbonate and acetate dialysis in stable chronic hemodialysis patients.
MedLine Citation:
PMID:  3891178     Owner:  NLM     Status:  MEDLINE    
Eight stable center dialysis patients completed four, 10-week study periods in which either acetate or bicarbonate dialysis was used, each with high or low sodium concentration. During high sodium dialysis, blood pressure was better controlled, weight loss more easily tolerated and dialysis was most satisfactory from the patient's point-of-view with regard to dialysis-associated symptoms. Low sodium dialysis, whether with acetate or bicarbonate, was less satisfactory. In contrast to the beneficial effect of an increased sodium concentration, the use of bicarbonate instead of acetate appeared to make little difference either to the patient's symptoms, to the control of blood pressure or to changes in blood gases or biochemistry. Careful choice of dialysate sodium concentration appears to be important in lessening dialysis side-effects. Substitution of bicarbonate for acetate in chronic stable dialysis patients has comparatively little benefit and the choice can legitimately be made on the basis of cost and technical considerations.
S Bijaphala; A J Bell; C A Bennett; S M Evans; J K Dawborn
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  23     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-08-09     Completed Date:  1985-08-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  179-83     Citation Subset:  IM    
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MeSH Terms
Acetates / administration & dosage*
Bicarbonates / administration & dosage*
Blood Pressure / drug effects
Body Weight / drug effects
Clinical Trials as Topic
Hydrogen-Ion Concentration
Middle Aged
Osmolar Concentration
Renal Dialysis*
Sodium / administration & dosage*
Reg. No./Substance:
0/Acetates; 0/Bicarbonates; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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