| Comparison of hepatic and extrahepatic drug-metabolizing enzyme activities in rats given single or multiple challenge infections with Fasciola hepatica. | |
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MedLine Citation:
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PMID: 8557466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The activity of drug-metabolizing enzymes was compared in liver, kidneys and lungs of rats given single or repetitive fluke infections. Fascioliasis was induced by oral administration of 20 metacercariae of F. hepatica to rats, either 6, or 12 and 6, or 12, 9 and 6 weeks before sacrifice. In the liver of mono-infected rats, significant reductions (24-67%) were observed in microsomal content of cytochrome P450 and all P450-dependent monooxygenases investigated. Conjugations to glutathione or acetate were lowered by 34-50% in these animals. In multiply infected animals, a majority of specific enzymatic activities were unchanged, while some monooxygenase activities such as aminopyrine demethylation or benzo(a)pyrene hydroxylation were increased by 26-76% in the liver of tri-infected rats. A renal compensatory process occurred in all infected groups, since cytochrome P450, benzphetamine demethylation and glutathione conjugation were significantly increased. By contrast, dealkylation of benzphetamine and pentoxyresorufin were decreased in the lungs of monoinfected rats. The development of parasite resistance would account for the recovery of liver drug metabolizing capabilities in multi-infected animals. |
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Authors:
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B Biro-Sauveur; C Eeckhoutte; E Baeza; C Boulard; P Galtier |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal for parasitology Volume: 25 ISSN: 0020-7519 ISO Abbreviation: Int. J. Parasitol. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1996-02-27 Completed Date: 1996-02-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0314024 Medline TA: Int J Parasitol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1193-200 Citation Subset: IM |
Affiliation:
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Laboratoire de Pharmacologie-Toxicologie INRA, Toulouse, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytochrome P-450 Enzyme System / metabolism Enzymes / metabolism* Fascioliasis / enzymology* Kidney / metabolism Liver / enzymology* Lung / metabolism Male Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Enzymes; 9035-51-2/Cytochrome P-450 Enzyme System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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