Document Detail

Comparison of heparin-coated and conventional split-tip hemodialysis catheters.
MedLine Citation:
PMID:  19488816     Owner:  NLM     Status:  MEDLINE    
Catheter coatings have the potential to decrease infection and thrombosis in patients with chronic dialysis catheters. We report our midterm experience with a heparin-coated dialysis catheter. This retrospective, case-control study was approved by our Institutional Review Board. A total of 88 tunneled dialysis catheters were inserted over a 13-month period via the internal jugular vein. Thirty-eight uncoated split-tip catheters and 50 heparin-coated catheters were inserted. Primary catheter patency was compared between the two groups using the log rank test, with infection and/or thrombosis considered as catheter failures. Dialysis parameters during the first and last dialysis sessions, including pump speed, actual blood flow, and arterial port pressures, were compared using unpaired t-tests. Primary patency of the uncoated catheters was 86.0 +/- 6.5% at 30 days and 76.1 +/- 8.9% at 90 days. Primary patency of heparin-coated catheters was 92.0 +/- 6.2% at 30 days and 81.6 +/- 8.0% at 90 days (p = 0.87, log rank test). Infection requiring catheter removal occurred in four patients with uncoated catheters and two patients with heparin-coated catheters (p = 0.23). Catheter thrombosis requiring catheter replacement or thrombolysis occurred in one patient with an uncoated catheter and two patients with heparin-coated catheters (p = 0.9). No differences in catheter function during hemodialysis were seen between the two groups. In conclusion, the heparin-coated catheter did not show a significantly longer patency compared to the uncoated catheter. The flow characteristics of this device were comparable to those of the conventional uncoated catheter. A demonstrable benefit of the heparin-coated catheter in randomized trials is needed before a recommendation for routine implementation can be made.
Timothy W I Clark; David Jacobs; Hearns W Charles; Sandor Kovacs; Theresa Aquino; Joseph Erinjeri; Judith A Benstein
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-06-02
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  32     ISSN:  1432-086X     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-06     Completed Date:  2009-12-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  703-6     Citation Subset:  IM    
Section of Vascular and Interventional Radiology, Department of Radiology, New York University School of Medicine, 560 First Avenue, HE-221, New York, NY 10016, USA.
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MeSH Terms
Case-Control Studies
Catheterization, Central Venous / instrumentation*
Coated Materials, Biocompatible
Jugular Veins
Radiography, Interventional
Renal Dialysis / instrumentation*
Retrospective Studies
Treatment Outcome
Ultrasonography, Interventional
Vascular Patency
Reg. No./Substance:
0/Coated Materials, Biocompatible; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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