| Comparison of hemostatic effects by route of H2 receptor antagonist administration following endoscopic mucosal resection in patients with neoplastic gastric lesions. | |
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MedLine Citation:
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PMID: 15943856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To date, there has not been an in-depth investigation to identify differences in the effects of bleeding prevention among different routes of administration of H2 receptor antagonists to treat gastric ulcers following endoscopic mucosal resection (EMR). AIM: To prospectively compare the frequency of bleeding following EMR between patients treated with intravenous (IV) famotidine and those with oral famotidine. METHODS: Fifty-three patients with neoplastic gastric lesions (33 carcinoma and 20 adenoma) treated by EMR were included. Subjects underwent EMR with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronate (EMRSH), followed by IV or oral (PO) administration of famotidine at a dosage of 40 mg/day for 2 days. Patients with odd ID numbers were assigned to IV therapy (30 cases) while even numbers were given PO therapy (23 cases). Frequencies and endoscopic findings of bleeding during the first 2 days after EMR were examined. RESULTS: Frequency of bleeding within 2 days after EMR was 3 and 4% in IV and PO patients, respectively, showing no significant difference. No significant difference was seen in the endoscopic findings of bleeding and therapy, either, with respective IV and PO findings at 23 and 26%. CONCLUSIONS: No significant difference was observed in frequency of bleeding within 2 days after gastric EMR between IV and oral administrations of famotidine. |
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Authors:
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K Satoh; H Yamamoto; H Kawata; H Osawa; K Hanatsuka; H Kita; K Sunada; T Hirasawa; M Yoshizawa; H Ajibe; Y Satoh; F Sunada; K Sugano |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 21 Suppl 2 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-09 Completed Date: 2005-08-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 105-10 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Jichi Medical School, Kawachi-gun, Tochigi, Japan. kiichi@jichi.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy*,
surgery Adjuvants, Immunologic / administration & dosage Administration, Oral Aged Endoscopy, Gastrointestinal / adverse effects Famotidine / administration & dosage* Female Gastrointestinal Hemorrhage / etiology, prevention & control* Hemostasis, Endoscopic / adverse effects Histamine H2 Antagonists / administration & dosage* Humans Hyaluronic Acid / administration & dosage Infusions, Intravenous Intestinal Mucosa / surgery Male Middle Aged Postoperative Hemorrhage / etiology, prevention & control* Prospective Studies Recurrence Stomach Neoplasms / drug therapy*, surgery |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Histamine H2 Antagonists; 76824-35-6/Famotidine; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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