Document Detail

Comparison of hemodynamic effects of lidocaine, prilocaine and mepivacaine solutions without vasoconstrictor in hypertensive patients.
MedLine Citation:
PMID:  20835569     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Local anesthetic solutions with vasoconstrictors are not contraindicated in hypertensive patients, but due to their hemodynamic effects, local anesthetics without vasoconstrictors are mainly preferred by the clinicians. The aim of this study was to compare hemodynamic effects of three different local anesthetics without vasoconstrictors during tooth extraction in hypertensive patients.
MATERIAL AND METHODS: Sixty-five mandibular molars and premolars were extracted in 60 hypertensive patients (29 females and 31 males; mean age: 66.95 ± 10.87 years; range: 38 to 86 years old). Inferior alveolar and buccal nerve blocks were performed with 2% lidocaine hydrochloride (HCl), 2% prilocaine HCl or 3% mepivacaine HCl without vasoconstrictor. Hemodynamic parameters namely systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), saturation rate (SR), rate pressure product (RPP) and pressure rate quotient (PRQ) were investigated before and at different intervals after anesthetic injection.
RESULTS: The hemodynamic effects of the three agents were similar to each other, although some significance was observed for DBP, MAP, RPP and PRQ values in the lidocaine, prilocaine and mepivacaine groups.
CONCLUSION: Lidocaine, prilocaine and mepivacaine solutions without vasoconstrictor can be safely used in hypertensive patients. It is advisable that dental practitioners select anesthetic solutions for hypertensive patients considering their cardiovascular effects in order to provide patient comfort and safety.
Bahadir Ezmek; Ahmet Arslan; Cagri Delilbasi; Kemal Sencift
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of applied oral science : revista FOB     Volume:  18     ISSN:  1678-7765     ISO Abbreviation:  J Appl Oral Sci     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101189774     Medline TA:  J Appl Oral Sci     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  354-9     Citation Subset:  D; IM    
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Aged, 80 and over
Anesthetics, Local / administration & dosage*
Bicuspid / surgery
Blood Pressure / drug effects
Calcium Channel Blockers / therapeutic use
Cheek / innervation
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / drug therapy,  physiopathology*
Lidocaine / administration & dosage*
Mandibular Nerve / drug effects
Mepivacaine / administration & dosage*
Middle Aged
Molar / surgery
Nerve Block / methods
Oxygen / blood
Prilocaine / administration & dosage*
Tooth Extraction
Vasoconstrictor Agents / administration & dosage
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Anesthetics, Local; 0/Calcium Channel Blockers; 0/Vasoconstrictor Agents; 137-58-6/Lidocaine; 721-50-6/Prilocaine; 7782-44-7/Oxygen; 96-88-8/Mepivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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