Document Detail

Comparison of hemodynamic effects of hyperbaric and isobaric bupivacaine in spinal anesthesia.
MedLine Citation:
PMID:  20422816     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Spinal anesthesia presents reversible interruption of nerve transmission within subarachniod space produced by injection of local anesthetic in cerebrospinal fluid. At the same time it comes to the blockade of particular functions of the nerve transmission. At the focus of this work is the blockade of sympathetic fibres which significantly affect on the behavior of the hemodynamic parameters. Change of these parameters may be very emphasized. One of the possible factors which may implicate is baricity of spinal anesthetic. The goals of the work are to determine how does the baricity affect the behavior of the basic hemodynamic parameters and also the height and distribution of the sensory block. METHODS: The research has been made on two groups who were given the same amount of 0.5% bupivacaine of different baricity; to the first group hyperbaric with 8.25% glucose and to the second an isobaric without any additives. At that time the application has been made on the same vertebral level, in same position. The research has been made on the patients in Hospital "Dr Irfan Ljubijankic" in Bihac. RESULTS: In hyperbaric group, systolic, mean, diastolic blood pressure and pulse frequency decreased 19.41%, 18.75%, 17.54% and 10.26% respectively, significantly greater than in isobaric group (7.22%, 2.65%, 1.62% and 9.38%). Gained results with high statistic significancy show that the baricity have an essential effect on the behavior of the basic hemodynamic parameters in the sense of reduction of the arterial blood pressure and slowing down of the pulse. At the same time isobaric anesthetic give smaller deviation of the parameters. CONCLUSION: By choosing the anesthetics of the appropriate baricity we can significantly affect hemodynamic status of the patient.
Nedim Solakovic
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Medicinski arhiv     Volume:  64     ISSN:  0350-199X     ISO Abbreviation:  Med Arh     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400722     Medline TA:  Med Arh     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  11-4     Citation Subset:  IM    
Department for Anesthesiology, Reanimation and Intensive Care, Cantonal Hospital "Dr Irfan Ljubijankic", Bihac, Bosnia and Herzegovina.
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MeSH Terms
Anesthesia, Spinal / methods*
Anesthetics, Local / administration & dosage,  pharmacology*
Blood Pressure / drug effects*
Bupivacaine / administration & dosage,  pharmacology*
Middle Aged
Reg. No./Substance:
0/Anesthetics, Local; 2180-92-9/Bupivacaine

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