Document Detail

Comparison of helium dilution and plethysmographic lung volumes in pregnant women.
MedLine Citation:
PMID:  9387967     Owner:  NLM     Status:  MEDLINE    
The multibreath helium equilibration method is the technique recommended for routine measurement of static lung volumes in normal subjects. However, pregnancy could be an exception to this general rule, due to airway closure during the second half of gestation. The aim of this study was to compare the measurements of lung volumes by plethysmography and helium dilution during pregnancy. Twenty three healthy women were studied at 12, 24 and 36 weeks of pregnancy, and 4 months postpartum. Total lung capacity (TLC), functional residual capacity (FRC) and residual volume (RV) were measured by multibreath helium equilibration (TLCHe, FRCHe and RVHe) and by plethysmography (TLCbox, FRCbox and RVbox). Only at 36 weeks were there differences between the two methods. RVbox was significantly larger than RVHe (1.01+/-0.18 vs 0.77+/-0.21 L; p<0.001). FRCbox was larger than FRCHe (1.95+/-0.32 vs 1.60+/-0.32 L; p<0.001) and TLCbox was larger than TLCHe (4.83+/-0.52 vs 4.45+/-0.51 L; p<0.05). The 95% limits of agreement for differences between lung volumes measured by the two techniques (helium dilution - plethysmography) at 36 weeks were: -0.42 to -0.06 L for RV; -0.54 to -0.17 L for FRC; and -0.66 to -0.11 L for TLC. We conclude that using the multibreath helium equilibration method to measure lung volumes in at-term pregnant women results in underestimation of functional residual capacity and total lung capacity.
F García-Río; J M Pino-García; S Serrano; M A Racionero; J G Terreros-Caro; R Alvarez-Sala; C Villasante; J Villamor
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  10     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-01-27     Completed Date:  1998-01-27     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  2371-5     Citation Subset:  IM    
Servicio de Neumología, Hospital Universitario La Paz, Madrid, Spain.
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MeSH Terms
Analysis of Variance
Helium / diagnostic use*
Lung Volume Measurements / instrumentation,  methods*
Pregnancy / physiology*
Respiratory Function Tests
Respiratory Physiological Phenomena*
Sensitivity and Specificity
Reg. No./Substance:

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