| Comparison of halothane and isoflurane for rapid anesthetic induction. | |
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MedLine Citation:
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PMID: 3300427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the hypothesis that isoflurane will induce anesthesia faster than halothane when given by a single vital capacity breath technique, we studied 20 ASA I and II adults who breathed approximately 4.5 MAC equivalents of either vapor. The patients, randomly assigned to receive either agent, were fully preoxygenated and monitored for cardiovascular, respiratory, and EEG parameters. All subjects were premedicated with 5 micrograms/kg fentanyl IV 5 min before induction. Time to loss of consciousness was significantly longer with halothane than with isoflurane (86 +/- 4 vs 38 +/- 2 sec, respectively) although there were no clinically remarkable differences in cardiovascular or respiratory variables. Patients given halothane had a greater excitatory phase on EEG, whereas those given isoflurane had low frequency predominance. Overall rapid inhalation induction was well-received by all patients and was significantly faster with isoflurane. |
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Authors:
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K Loper; J Reitan; H Bennett; J Benthuysen; L Snook |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 66 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1987 Aug |
Date Detail:
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Created Date: 1987-08-24 Completed Date: 1987-08-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 766-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, Inhalation* Cardiovascular System / drug effects Clinical Trials as Topic Electroencephalography Halothane / pharmacology* Humans Isoflurane / pharmacology* Random Allocation Respiration / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
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151-67-7/Halothane; 26675-46-7/Isoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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