Document Detail


Comparison of the haemodynamic actions of neuropeptide Y, angiotensin II and noradrenaline in anaesthetised cats.
MedLine Citation:
PMID:  3754217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood pressure, heart rate, cardiac output, renal flow and femoral flow were recorded in open-chested anaesthetised cats. Dose-response curves were constructed for neuropeptide Y, angiotensin II and noradrenaline after pretreatment with atropine sulphate. Neuropeptide Y, on a molar basis, was 7 and 120 times less potent than noradrenaline and angiotensin, respectively, in producing a 50 mm Hg rise in mean arterial blood pressure. The pressor effect of neuropeptide Y was characterised by dose-dependent increases in total peripheral, renal and femoral resistance with little change in cardiac output. Neuropeptide Y had a similar potency to noradrenaline in causing these resistance changes. However, the pressor response to noradrenaline was associated with a dose-dependent increase in cardiac output. The pressor action of neuropeptide Y was not attenuated by adrenoceptor blockade by phenoxybenzamine (5 mg kg-1) and propranolol (1 mg kg-1).
Authors:
R Corder; P J Lowry; S J Wilkinson; A G Ramage
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  121     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-04-30     Completed Date:  1986-04-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthesia
Angiotensin II / pharmacology*
Animals
Blood Pressure / drug effects
Cardiac Output / drug effects
Cats
Dose-Response Relationship, Drug
Heart Rate / drug effects
Hemodynamics / drug effects*
Male
Nerve Tissue Proteins / pharmacology*
Neuropeptide Y
Norepinephrine / pharmacology*
Regional Blood Flow / drug effects
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Neuropeptide Y; 11128-99-7/Angiotensin II; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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