| Comparison of gene expression in hepatocellular carcinoma, liver development, and liver regeneration. | |
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MedLine Citation:
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PMID: 20358383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Proliferation of liver cells can be observed in hepatocarcinogenesis, at different stages of liver development, and during liver regeneration after an injury. Does it imply that they share similar molecular mechanisms? Here, the transcriptional profiles of hepatocellular carcinoma (HCC), liver development, and liver regeneration were systematically compared as a preliminary attempt to answer this question. From the comparison, we found that advanced HCC mimics early development in terms of deprived normal liver functions and activated cellular proliferation, but advanced HCC and early development differ in expressions of cancer-related genes and their transcriptional controls. HCC and liver regeneration demonstrate different expression patterns as a whole, but regeneration is similar to dysplasia (pre-stage of HCC) in terms of their proximity to the normal state. In summary, of these three important processes, the carcinogenic progress carries the highest variance in expression; HCC pre-stage shares some resemblance with liver regeneration; and advanced HCC stage displays similarity with early development. |
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Authors:
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Tingting Li; Bingbing Wan; Jian Huang; Xuegong Zhang |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-01 |
Journal Detail:
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Title: Molecular genetics and genomics : MGG Volume: 283 ISSN: 1617-4623 ISO Abbreviation: Mol. Genet. Genomics Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093320 Medline TA: Mol Genet Genomics Country: Germany |
Other Details:
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Languages: eng Pagination: 485-92 Citation Subset: IM |
Affiliation:
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Department of Biomedical Informatics, Peking University Health Science Center, 38 Xueyuan Rd, Beijing, 100191, China. litt@hsc.pku.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / genetics*, pathology Cluster Analysis Gene Expression Profiling Gene Expression Regulation, Developmental* Gene Expression Regulation, Neoplastic* Liver / embryology*, metabolism*, pathology Liver Neoplasms / genetics*, pathology Liver Regeneration / genetics* Mice Mice, Inbred C57BL Neoplasm Proteins / genetics, metabolism Neoplasm Staging Principal Component Analysis Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Neoplasm Proteins |
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