Document Detail

Comparison of gene expression in hepatocellular carcinoma, liver development, and liver regeneration.
MedLine Citation:
PMID:  20358383     Owner:  NLM     Status:  MEDLINE    
Proliferation of liver cells can be observed in hepatocarcinogenesis, at different stages of liver development, and during liver regeneration after an injury. Does it imply that they share similar molecular mechanisms? Here, the transcriptional profiles of hepatocellular carcinoma (HCC), liver development, and liver regeneration were systematically compared as a preliminary attempt to answer this question. From the comparison, we found that advanced HCC mimics early development in terms of deprived normal liver functions and activated cellular proliferation, but advanced HCC and early development differ in expressions of cancer-related genes and their transcriptional controls. HCC and liver regeneration demonstrate different expression patterns as a whole, but regeneration is similar to dysplasia (pre-stage of HCC) in terms of their proximity to the normal state. In summary, of these three important processes, the carcinogenic progress carries the highest variance in expression; HCC pre-stage shares some resemblance with liver regeneration; and advanced HCC stage displays similarity with early development.
Tingting Li; Bingbing Wan; Jian Huang; Xuegong Zhang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-01
Journal Detail:
Title:  Molecular genetics and genomics : MGG     Volume:  283     ISSN:  1617-4623     ISO Abbreviation:  Mol. Genet. Genomics     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101093320     Medline TA:  Mol Genet Genomics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  485-92     Citation Subset:  IM    
Department of Biomedical Informatics, Peking University Health Science Center, 38 Xueyuan Rd, Beijing, 100191, China.
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MeSH Terms
Carcinoma, Hepatocellular / genetics*,  pathology
Cluster Analysis
Gene Expression Profiling
Gene Expression Regulation, Developmental*
Gene Expression Regulation, Neoplastic*
Liver / embryology*,  metabolism*,  pathology
Liver Neoplasms / genetics*,  pathology
Liver Regeneration / genetics*
Mice, Inbred C57BL
Neoplasm Proteins / genetics,  metabolism
Neoplasm Staging
Principal Component Analysis
Time Factors
Reg. No./Substance:
0/Neoplasm Proteins

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