| Comparison of gemeprost and vaginal misoprostol in first trimester mifepristone-induced abortion. | |
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MedLine Citation:
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PMID: 15964289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to compare efficacy and side effects of gemeprost and vaginal misoprostol in mifepristone-induced abortions in women up to 63 days of gestation. METHODS: A retrospective study of 833 consecutive patients admitted for medical termination of first trimester pregnancy was conducted. Four-hundred ten patients received mifepristone 600 mg, followed 48 h later by gemeprost 1 mg (regimen I), and 423 patients received mifepristone 200 mg followed by vaginal misoprostol 800 microg (regimen II). Success rates were evaluated after 2 weeks and after 3 months. The severity of bleeding and side effects (pain, nausea, vomiting and diarrhea) was scored by the patients, and requests for supplementary analgesic treatment were recorded by the attending nurse. RESULTS: Success rates were 99% in both groups after 2 weeks of follow-up. At 3 months of follow-up, success rates had declined to 94% for regimen I and 96% for regimen II. The frequency of severe pain was higher in regimen I compared to regimen II (72% vs. 60%, p < .001), but the severity of bleeding and gastrointestinal side effects was similar in the two regimens. CONCLUSION: When combined with mifepristone, gemeprost and vaginal misoprostol are equally effective for termination of first trimester abortion, but may be associated with varying intensity of side effects. |
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Authors:
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Pernille Fog Svendsen; Christina Rørbye; Thomas Vejborg; Lisbeth Nilas |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Contraception Volume: 72 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-20 Completed Date: 2005-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
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Languages: eng Pagination: 28-32 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Copenhagen University Hospital, 2650 Hvidovre, Copenhagen, Denmark. pernillefsvendsen@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage*,
adverse effects Abortion, Induced* Adult Alprostadil / administration & dosage, adverse effects, analogs & derivatives* Chorionic Gonadotropin / blood Female Gestational Age* Humans Misoprostol / administration & dosage*, adverse effects Pregnancy Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 0/Chorionic Gonadotropin; 59122-46-2/Misoprostol; 64318-79-2/gemeprost; 745-65-3/Alprostadil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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