Document Detail


Comparison of gastric mucosal surface pH response times after intravenous administration of histamine2-receptor antagonists.
MedLine Citation:
PMID:  7585847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gastric mucosal surface pH was measured endoscopically in patients with peptic ulcer, erosive gastritis, or nonulcer dyspepsia following intravenous administration of either 200-mg cimetidine, 50-mg ranitidine, or 40-mg famotidine. The mean baseline pH in the three treatment groups before drug administration ranged from 0.85 to 0.99, with no significant difference between groups. Following treatment with cimetidine, ranitidine, and famotidine, the mean response times for the mucosal surface pH values to increase to 3.5 were 10.1 +/- 5.9 minutes, 11.2 +/- 6.8 minutes, and 17.3 +/- 6.7 minutes, respectively. The corresponding response times to reach pH levels of 6.0 were 16.0 +/- 9.4 minutes, 17.0 +/- 5.4 minutes, and 31.2 +/- 21.7 minutes, respectively. The response times to pH levels of 3.5 and 6.0 were significantly faster in patients who received cimetidine compared with patients who received famotidine (P = 0.0088 to pH 3.5 and P = 0.046 to pH 6.0). The differences between cimetidine and ranitidine were not significant. These findings suggest that at recommended clinical doses, intravenous cimetidine provides rapid elevation of the gastric mucosal surface pH compared with other histamine2-receptor antagonists. This finding may be particularly relevant in the emergency care of patients with severe peptic ulcer disease (eg, patients with gastrointestinal hemorrhage).
Authors:
K Katsu; S Yabe
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical therapeutics     Volume:  17     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:    1995 May-Jun
Date Detail:
Created Date:  1995-12-04     Completed Date:  1995-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  433-10     Citation Subset:  IM    
Affiliation:
Third Division of Internal Medicine, Saitama Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cimetidine / administration & dosage,  pharmacology
Famotidine / administration & dosage,  pharmacology
Female
Gastric Acid / metabolism*
Gastric Acidity Determination
Gastric Mucosa / drug effects,  metabolism*
Histamine H2 Antagonists / administration & dosage,  pharmacology*
Humans
Hydrogen-Ion Concentration
Injections, Intravenous
Male
Middle Aged
Peptic Ulcer / metabolism
Ranitidine / administration & dosage,  pharmacology
Surface Properties
Time Factors
Chemical
Reg. No./Substance:
0/Histamine H2 Antagonists; 51481-61-9/Cimetidine; 66357-35-5/Ranitidine; 76824-35-6/Famotidine

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