| Comparison of gastric mucosal surface pH response times after intravenous administration of histamine2-receptor antagonists. | |
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MedLine Citation:
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PMID: 7585847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastric mucosal surface pH was measured endoscopically in patients with peptic ulcer, erosive gastritis, or nonulcer dyspepsia following intravenous administration of either 200-mg cimetidine, 50-mg ranitidine, or 40-mg famotidine. The mean baseline pH in the three treatment groups before drug administration ranged from 0.85 to 0.99, with no significant difference between groups. Following treatment with cimetidine, ranitidine, and famotidine, the mean response times for the mucosal surface pH values to increase to 3.5 were 10.1 +/- 5.9 minutes, 11.2 +/- 6.8 minutes, and 17.3 +/- 6.7 minutes, respectively. The corresponding response times to reach pH levels of 6.0 were 16.0 +/- 9.4 minutes, 17.0 +/- 5.4 minutes, and 31.2 +/- 21.7 minutes, respectively. The response times to pH levels of 3.5 and 6.0 were significantly faster in patients who received cimetidine compared with patients who received famotidine (P = 0.0088 to pH 3.5 and P = 0.046 to pH 6.0). The differences between cimetidine and ranitidine were not significant. These findings suggest that at recommended clinical doses, intravenous cimetidine provides rapid elevation of the gastric mucosal surface pH compared with other histamine2-receptor antagonists. This finding may be particularly relevant in the emergency care of patients with severe peptic ulcer disease (eg, patients with gastrointestinal hemorrhage). |
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Authors:
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K Katsu; S Yabe |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Clinical therapeutics Volume: 17 ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 1995 May-Jun |
Date Detail:
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Created Date: 1995-12-04 Completed Date: 1995-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 433-10 Citation Subset: IM |
Affiliation:
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Third Division of Internal Medicine, Saitama Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cimetidine / administration & dosage, pharmacology Famotidine / administration & dosage, pharmacology Female Gastric Acid / metabolism* Gastric Acidity Determination Gastric Mucosa / drug effects, metabolism* Histamine H2 Antagonists / administration & dosage, pharmacology* Humans Hydrogen-Ion Concentration Injections, Intravenous Male Middle Aged Peptic Ulcer / metabolism Ranitidine / administration & dosage, pharmacology Surface Properties Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Histamine H2 Antagonists; 51481-61-9/Cimetidine; 66357-35-5/Ranitidine; 76824-35-6/Famotidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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