Document Detail

Comparison of gastric emptying and plasma ghrelin levels in patients with functional dyspepsia and non-erosive reflux disease.
MedLine Citation:
PMID:  19246923     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: The symptoms of postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS), the two subtypes of functional dyspepsia (FD) under the new Rome III classification, tend to overlap with those of non-erosive reflux disease (NERD). Plasma ghrelin levels have been associated with gastric motility; however, clinical studies have yet to examine this relationship among patients with PDS, EPS or NERD. Thus, this study aims to evaluate the correlation between gastric emptying and ghrelin levels as possible candidate factors for gastric motility in these diseases. METHODS: One hundred and fifty-one patients presenting with typical symptoms of FD (EPS, n = 36; PDS, n = 76) or NERD (n = 39), and 20 healthy volunteers were enrolled. Gastric motility was evaluated with the T(max) value as a marker of gastric emptying using the 13C-acetate breath test. We used Rome III criteria to evaluate upper abdominal symptoms, and SRQ-D scores to determine depression status. We measured both acylated and des-acylated ghrelin levels by ELISA methods. RESULTS: The Tmax value in PDS patients was significantly higher than in healthy volunteers. Acylated ghrelin levels were significantly lower in NERD and PDS patients than in healthy volunteers. Interestingly, there was significant correlation between the acylated ghrelin levels and Tmax value in PDS patients but not in EPS or NERD patients. CONCLUSION: Our results suggest that acylated ghrelin might play an important role in the pathophysiology of PDS patients through its effect on gastric emptying.
Tomotaka Shindo; Seiji Futagami; Tetsuro Hiratsuka; Akane Horie; Tatsuhiko Hamamoto; Nobue Ueki; Masafumi Kusunoki; Kazumasa Miyake; Katya Gudis; Taku Tsukui; Katsuhiko Iwakiri; Choitsu Sakamoto
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-02-27
Journal Detail:
Title:  Digestion     Volume:  79     ISSN:  1421-9867     ISO Abbreviation:  Digestion     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School, Tokyo 113-8602, Japan.
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MeSH Terms
Breath Tests
Carbon Isotopes / analysis
Case-Control Studies
Dyspepsia / blood,  pathology,  physiopathology*
Gastric Emptying*
Gastric Mucosa / pathology
Gastroesophageal Reflux / blood,  pathology,  physiopathology*
Ghrelin / blood*
Logistic Models
Middle Aged
Reg. No./Substance:
0/Carbon Isotopes; 0/Ghrelin

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