Document Detail

Comparison of gastric, duodenal and jejunal contributions to the inhibition of food intake in the rat.
MedLine Citation:
PMID:  6537525     Owner:  NLM     Status:  MEDLINE    
Rats equipped with tubes leading to their stomach, duodenum or jejunum were infused with a liquid diet for 9 hr (4 ml/hr) and were allowed to eat during the last 8 hr of infusion. All rats ate significantly less on diet infusion days than on saline or no infusion days. A second study showed that a taste aversion could not be conditioned to flavored water associated with diet infusion. Apparently, intrajejunal injection of nutrients produces satiety and not discomfort. Infusion of the diet for 5 consecutive days into the stomach, duodenum or jejunum consistently and significantly lowered food intake by reducing meal size, not meal frequency. Results suggest that the small intestine below the infusion site contributes to normal satiety.
R S Canbeyli; H S Koopmans
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  33     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-10-24     Completed Date:  1985-10-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  951-7     Citation Subset:  IM    
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MeSH Terms
Duodenum / physiology*
Feeding Behavior
Jejunum / physiology*
Rats, Inbred Strains
Satiety Response
Stomach / physiology*
Time Factors
Grant Support

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