Document Detail


Comparison of gadolinium chelates with manganese-DPDP for liver lesion detection and characterization: preliminary results.
MedLine Citation:
PMID:  9065909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nonspecific extracellular gadolinium chelate (NEGd) was prospectively compared with managanese (Mn)-DPDP (Mn) for the detection and characterization of focal liver lesions of various histology. Seventeen patients with known or suspected focal liver lesions underwent NEGd and Mn-enhanced studies at 1.5 T. Study findings were correlated with histology (five patients), computed tomography (CT) examinations (17 patients), and 4- to 13-month imaging follow-up by CT and/or MR (five patients). NEGd studies were performed as serial postcontrast spoiled gradient echo (SGE) sequences, and Mn studies were performed as SGE sequences 15 and 30 min postocontrast and T1-weighted, fat-suppressed spin echo at 16 min. NEGd and Mn images were prospectively interpreted in a separate blinded fashion. Lesion detection and characterization were determined. NEGd and Mn-enhanced images demonstrated 61 and 49 lesions, respectively (p = .1, NS). A total of 60 and 33 lesions were characterized on NEGd and Mn images, respectively, which was significantly different (p = .008). No differences were observed for the detection and characterization of liver metastases; whereas there was a trend for superior detection and characterization for hepatocellular carcinoma with NEGA.
Authors:
U Kettritz; J F Schlund; K Wilbur; L B Eisenberg; R C Semelka
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  14     ISSN:  0730-725X     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  1996  
Date Detail:
Created Date:  1997-05-23     Completed Date:  1997-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1185-90     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of North Carolina at Chapel Hill 27599, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carcinoma, Hepatocellular / diagnosis
Contrast Media*
Cysts / diagnosis
Edetic Acid / analogs & derivatives*,  diagnostic use
Female
Gadolinium / diagnostic use*
Gadolinium DTPA
Hemangioma / diagnosis
Humans
Liver Diseases / diagnosis
Liver Neoplasms / diagnosis*,  radiography,  secondary
Magnetic Resonance Imaging*
Male
Manganese / diagnostic use*
Middle Aged
Organometallic Compounds / diagnostic use
Pentetic Acid / analogs & derivatives,  diagnostic use
Prospective Studies
Pyridoxal Phosphate / analogs & derivatives*,  diagnostic use
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Organometallic Compounds; 119797-12-5/N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid; 122795-43-1/gadodiamide; 54-47-7/Pyridoxal Phosphate; 60-00-4/Edetic Acid; 67-43-6/Pentetic Acid; 7439-96-5/Manganese; 7440-54-2/Gadolinium; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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