Document Detail


Comparison of fundus autofluorescence with photopic and scotopic fine matrix mapping in patients with retinitis pigmentosa: 4- to 8-year follow-up.
MedLine Citation:
PMID:  22899761     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To assess the significance and evolution of parafoveal rings of high-density fundus autofluorescence (AF) in 12 patients with retinitis pigmentosa (RP).
METHODS: Twelve patients with autosomal recessive RP or Usher syndrome type 2 were ascertained who had a parafoveal ring of high-density AF and a visual acuity of 20/30 or better at baseline. Photopic and scotopic fine matrix mapping (FMM) were performed to test sensitivity across the macula. AF imaging and FMM were repeated after 4 to 8 years and optical coherence tomography (OCT) performed.
RESULTS: The size of the AF ring reduced over time and disappeared in one subject. Photopic thresholds were normal over the fovea; thresholds were elevated by 0.6 log units over the ring and by 1.2 log units external to the ring at baseline and differed by less than 0.1 log unit at follow-up. Mild photopic losses close to the internal edge of the ring were detected at baseline or follow-up in all. Mean scotopic thresholds over parafoveal areas within the ring were markedly elevated in 8 of 10 at baseline and were severely elevated in 9 of 11 at follow-up. The eccentricity of the inner edge of the AF ring corresponded closely with the lateral extent of the inner segment ellipsoid band in the OCT image.
CONCLUSIONS: Ring constriction was largely coincident with progressive centripetal photopic threshold elevation led by worsening of rod photoreceptor function. The rate of constriction differed across patients, and a ring may reach a critical minimum before disappearing, at which stage central visual loss occurs. The structural and functional changes associated with rings of increased autofluorescence confirm that they provide an objective index of macular involvement and may aid the management of RP patients and the monitoring of future treatment efficacy.
Authors:
Anthony G Robson; Eva Lenassi; Zubin Saihan; Vy A Luong; Fred W Fitzke; Graham E Holder; Andrew R Webster
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-14
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  53     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-17     Completed Date:  2012-11-26     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6187-95     Citation Subset:  IM    
Affiliation:
Moorfields Eye Hospital, London, United Kingdom. anthony.robson@moorfields.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Ocular / physiology
Adolescent
Adult
Color Vision / physiology*
Female
Fluorescence*
Follow-Up Studies
Fundus Oculi*
Humans
Male
Middle Aged
Night Vision / physiology*
Retina / physiopathology*
Retinal Cone Photoreceptor Cells / physiology
Retinal Rod Photoreceptor Cells / physiology
Retinitis Pigmentosa / physiopathology*
Sensory Thresholds / physiology
Visual Acuity / physiology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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