Document Detail

Comparison of functional and morphological deficits in the rat after gestational exposure to ionizing radiation.
MedLine Citation:
PMID:  3226380     Owner:  NLM     Status:  MEDLINE    
Ionizing radiation is a precise tool for altering formation of the developing cerebral cortex of the fetal rat. Whole body exposure of the pregnant rat on gestational day 13, 15 or 17 to 1.0 Gy of gamma radiation resulted in maximum thinning of the cortex on days 15 and 17. In the preweaning period, functional tests (negative geotaxis, reflex suspension, continuous corridor and gait) were most affected by irradiation gestational day 15, as was body weight. When a lower dose of radiation (0.75 Gy) was used on gestational day 15, the damage to the cortex was much less but behavioral changes were still present. Frontal, parietal and occipital areas of the cortex were approximately equally affected. Using stepwise multiple regression analysis, the linkage of functional tests and cortical thickness was examined. Functional variables which were most commonly included as predictors of frontal and parietal cortex were negative geotaxis and continuous corridor. Occipital cortical layers were not predicted by behavioral variables. In predicting function using cortical variables, frontal cortex was better than parietal and occipital cortex was the poorest predictor.
S Norton; B F Kimler
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  10     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    1988 Jul-Aug
Date Detail:
Created Date:  1989-03-29     Completed Date:  1989-03-29     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  363-71     Citation Subset:  IM    
Department of Pharmacology, University of Kansas Medical Center, Kansas City 66103.
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MeSH Terms
Cerebral Cortex / cytology,  growth & development,  radiation effects*
Gestational Age
Motor Activity / radiation effects*
Prenatal Exposure Delayed Effects*
Regression Analysis
Grant Support

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