Document Detail

Comparison of functional MR-venography and EPI-BOLD fMRI at 1.5 T.
MedLine Citation:
PMID:  9814782     Owner:  NLM     Status:  MEDLINE    
Functional magnetic resonance imaging (fMRI) of the brain using blood oxygenation level dependent (BOLD) contrast relies on the changes of paramagnetic deoxyhemoglobin concentration, which affects brain parenchyma and draining venous vessels. These changes in deoxyhemoglobin concentration in venous vessels can also be monitored using a high-resolution susceptibility-based MR-venography technique. Four volunteers participated in the study in which functional MR-venograms were compared with conventional echo-planar imaging (EPI)-BOLD-fMRI. In all cases, small venous vessels could be identified close to the areas of activation detected by conventional fMRI. In the venograms, task performance (finger tapping) resulted in a loss of venous vessel contrast compared to the resting state, which is consistent with a local decrease of deoxyhemoglobin concentration. MR-venography allows a direct visualization of the BOLD-effect at high spatial resolution. In combination with conventional fMRI, this technique may help to separate the contribution of brain parenchyma and venous vessels in fMRI studies.
K T Baudendistel; J R Reichenbach; R Metzner; J Schroeder; L R Schad
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  16     ISSN:  0730-725X     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-20     Completed Date:  1999-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  989-91     Citation Subset:  IM    
Department of Radiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
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MeSH Terms
Brain / blood supply*
Echo-Planar Imaging / methods*
Magnetic Resonance Angiography / methods*
Magnetic Resonance Imaging / methods*
Veins / anatomy & histology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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