Document Detail

Comparison of the frequency of abnormal cardiac findings by echocardiography in patients with and without peripheral arterial disease.
MedLine Citation:
PMID:  17293193     Owner:  NLM     Status:  MEDLINE    
Peripheral arterial disease (PAD) diagnosed by ankle-brachial index (ABI) evaluation is associated with a high cardiovascular mortality rate. Transthoracic echocardiography (TTE) allows identification of left ventricular (LV) dysfunction and other cardiac findings associated with an increased cardiovascular mortality rate, for which treatments to alter prognosis are available. We sought to determine the prevalence of important TTE abnormalities in outpatients with symptomatic PAD by performing screening TEE. Outpatients without previous echocardiography who had been referred for ABI evaluation for suspected PAD underwent prospective screening TTE. The primary end points were LV dysfunction (LV ejection fraction <or=54%) and the composite of any clinically important echocardiographic finding. Patients confirmed to have PAD (ABI <or=0.9, n = 120) were found to have a high prevalence of LV dysfunction (26.7%), marked LV dysfunction (LV ejection fraction <45%) (14.2%), aortic stenosis (5.0%), and composite of any clinically important finding (36.7%). Patients with PAD had significantly more LV dysfunction and composite clinically important findings than patients without PAD (ABI >0.9, n = 84), and PAD was found to be an independent predictor of LV dysfunction (odds ratio 2.8, 95% confidence interval 1.2 to 6.4) and composite clinically important echocardiographic findings (3.2 95% confidence interval 1.5 to 7.1, p <0.01). In conclusion, outpatients with symptomatic PAD have a high prevalence of clinically important TTE abnormalities, including LV dysfunction, and PAD is an independent predictor of an abnormal echocardiogram.
R Parker Ward; Sascha N Goonewardena; Georgeanne Lammertin; Roberto M Lang
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-12-28
Journal Detail:
Title:  The American journal of cardiology     Volume:  99     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-12     Completed Date:  2007-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  499-503     Citation Subset:  AIM; IM    
Non-Invasive Imaging Laboratories, Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois, USA.
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MeSH Terms
Logistic Models
Middle Aged
Peripheral Vascular Diseases / complications*,  ultrasonography
Prospective Studies
Ventricular Dysfunction, Left / complications*,  epidemiology,  ultrasonography*

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